SLK (gene)

SLK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2J51, 2JFL, 2JFM, 2UV2, 4USF
Identifiers
Aliases	SLK, LOSK, STK2, bA16H23.1, se20-9, STE20 like kinase
External IDs	OMIM: 616563; MGI: 103241; HomoloGene: 22515; GeneCards: SLK; OMA:SLK - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	104,029,233 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	47,633,685 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; amniotic fluid; ; glomerulus; ; metanephric glomerulus; ; Achilles tendon; ; Epithelium of choroid plexus; ; Brodmann area 23; ; oral cavity; ; gingival epithelium; ; mucosa of pharynx;
	Top expressed in
	Ileal epithelium; ; genital tubercle; ; gastrula; ; aortic valve; ; tail of embryo; ; ciliary body; ; ascending aorta; ; Paneth cell; ; retinal pigment epithelium; ; saccule;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein homodimerization activity; kinase activity; protein serine/threonine kinase activity; protein binding; identical protein binding; ATP binding; cadherin binding;
Cellular component	extracellular exosome; cell leading edge; perinuclear region of cytoplasm; cytoplasm;
Biological process	phosphorylation; protein phosphorylation; cytoplasmic microtubule organization; regulation of focal adhesion assembly; protein autophosphorylation; apoptotic process; regulation of cell migration; regulation of apoptotic process; regulation of mitotic cell cycle; signal transduction; stress-activated protein kinase signaling cascade; activation of protein kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	9748
	20874
	ENSG00000065613
	ENSMUSG00000025060
	Q9H2G2
	O54988
	NM_001304743; NM_014720
	NM_001164639; NM_009289
	NP_001291672; NP_055535
	NP_001158111; NP_033315
	Wikidata
View/Edit Human	View/Edit Mouse

STE20-like serine/threonine-protein kinase is an enzyme that in humans is encoded by the SLK gene.^[5]^[6]

Interactions

SLK (gene) has been shown to interact with PDZK1.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000065613 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025060 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Celenza JL, Carlson M (Sep 1986). "A yeast gene that is essential for release from glucose repression encodes a protein kinase". Science. 233 (4769): 1175–80. doi:10.1126/science.3526554. PMID 3526554.
^ "Entrez Gene: SLK STE20-like kinase (yeast)".
^ Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.

Yan Y, Nguyen H, Dalmasso G, Sitaraman SV, Merlin D (Feb 2007). "Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform". Biochimica et Biophysica Acta. 1769 (2): 106–16. doi:10.1016/j.bbaexp.2007.01.003. PMC 1865517. PMID 17321610.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Chaar Z, O'reilly P, Gelman I, Sabourin LA (Sep 2006). "v-Src-dependent down-regulation of the Ste20-like kinase SLK by casein kinase II". The Journal of Biological Chemistry. 281 (38): 28193–9. doi:10.1074/jbc.M605665200. PMID 16837460.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
Nakayama M, Kikuno R, Ohara O (Nov 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Dan I, Watanabe NM, Kusumi A (May 2001). "The Ste20 group kinases as regulators of MAP kinase cascades". Trends in Cell Biology. 11 (5): 220–30. doi:10.1016/S0962-8924(01)01980-8. PMID 11316611.
Eichmuller S, Usener D, Dummer R, Stein A, Thiel D, Schadendorf D (Jan 2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proceedings of the National Academy of Sciences of the United States of America. 98 (2): 629–34. doi:10.1073/pnas.021386498. PMC 14639. PMID 11149944.
Yamada E, Tsujikawa K, Itoh S, Kameda Y, Kohama Y, Yamamoto H (Feb 2000). "Molecular cloning and characterization of a novel human STE20-like kinase, hSLK". Biochimica et Biophysica Acta. 1495 (3): 250–62. doi:10.1016/S0167-4889(99)00164-0. PMID 10699464.
Sabourin LA, Tamai K, Seale P, Wagner J, Rudnicki MA (Jan 2000). "Caspase 3 cleavage of the Ste20-related kinase SLK releases and activates an apoptosis-inducing kinase domain and an actin-disassembling region". Molecular and Cellular Biology. 20 (2): 684–96. doi:10.1128/MCB.20.2.684-696.2000. PMC 85169. PMID 10611247.
Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N (Oct 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000065613 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025060 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3526554-5] Celenza JL, Carlson M (Sep 1986). "A yeast gene that is essential for release from glucose repression encodes a protein kinase". Science. 233 (4769): 1175–80. doi:10.1126/science.3526554. PMID 3526554.

[entrez-6] "Entrez Gene: SLK STE20-like kinase (yeast)".

[pmid14531806-7] Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.

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Interactions

References

Further reading