SMPD2

SMPD2
Identifiers
Aliases	SMPD2, ISC1, NSMASE, NSMASE1, sphingomyelin phosphodiesterase 2
External IDs	OMIM: 603498; MGI: 1278330; HomoloGene: 31129; GeneCards: SMPD2; OMA:SMPD2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	109,443,919 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	41,366,365 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; left testis; ; right testis; ; mucosa of transverse colon; ; olfactory zone of nasal mucosa; ; sperm; ; gingival epithelium; ; bronchial epithelial cell; ; granulocyte; ; skin of abdomen;
	Top expressed in
	right kidney; ; proximal tubule; ; yolk sac; ; human kidney; ; saccule; ; jejunum; ; retinal pigment epithelium; ; granulocyte; ; duodenum; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sphingomyelin phosphodiesterase activity; metal ion binding; hydrolase activity;
Cellular component	integral component of membrane; membrane; plasma membrane; integral component of plasma membrane; intracellular anatomical structure; caveola;
Biological process	positive regulation of ceramide biosynthetic process; intracellular signal transduction; lipid metabolism; ceramide biosynthetic process; response to mechanical stimulus; sphingomyelin metabolic process; sphingolipid metabolic process; sphingomyelin catabolic process; glycosphingolipid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	6610
	20598
	ENSG00000135587
	ENSMUSG00000019822
	O60906
	O70572
	NM_003080
	NM_009213
	NP_003071
	NP_033239
	Wikidata
View/Edit Human	View/Edit Mouse

Sphingomyelin phosphodiesterase 2 is an enzyme that in humans is encoded by the SMPD2 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135587 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019822 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tomiuk S; Hofmann K; Nix M; Zumbansen M; Stoffel W (May 1998). "Cloned mammalian neutral sphingomyelinase: functions in sphingolipid signaling?". Proc Natl Acad Sci U S A. 95 (7): 3638–3643. doi:10.1073/pnas.95.7.3638. PMC 19888. PMID 9520418.
^ "Entrez Gene: SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)".

References

Further reading