SMPD3

SMPD3
Identifiers
Aliases	SMPD3, NSMASE2, sphingomyelin phosphodiesterase 3
External IDs	OMIM: 605777; MGI: 1927578; HomoloGene: 10260; GeneCards: SMPD3; OMA:SMPD3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	68,448,508 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	107,064,620 bp
RNA expression pattern
	Top expressed in
	tibia; ; duodenum; ; periodontal fiber; ; thymus; ; jejunal mucosa; ; ganglionic eminence; ; mucosa of transverse colon; ; putamen; ; right hemisphere of cerebellum; ; rectum;
	Top expressed in
	membranous bone; ; Dermatocranium; ; calvaria; ; mandible; ; maxilla; ; lumbar spinal ganglion; ; olfactory tubercle; ; long bone; ; body of femur; ; molar;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sphingomyelin phosphodiesterase activity; metal ion binding; hydrolase activity; protein binding; neutral sphingomyelin phosphodiesterase activity; phospholipase activity;
Cellular component	Golgi apparatus; membrane; Golgi membrane; Golgi cis cisterna; plasma membrane; cytoplasm;
Biological process	positive regulation of ceramide biosynthetic process; lipid metabolism; multicellular organism development; sphingomyelin catabolic process; peptide hormone secretion; hematopoietic progenitor cell differentiation; cell cycle; positive regulation of exosomal secretion; sphingomyelin metabolic process; sphingolipid metabolic process; skeletal system development; endochondral ossification; chondrocyte development; regulation of leukocyte migration; bone mineralization; BMP signaling pathway; multicellular organism growth; protein kinase B signaling; cartilage development; protein homooligomerization; bone development; regulation of cartilage development; cellular response to redox state; bone growth; cellular response to peptide; ossification; regulation of protein phosphorylation; chondrocyte development involved in endochondral bone morphogenesis; ceramide metabolic process; glycosphingolipid metabolic process; signal transduction; polysaccharide transport; lung development; collagen metabolic process; cellular response to reactive oxygen species; positive regulation of mitotic nuclear division; platelet-derived growth factor receptor signaling pathway; lung alveolus development; positive regulation of smooth muscle cell proliferation; respiratory system development; cellular response to hydrogen peroxide; G1 to G0 transition; cellular response to magnesium ion; cellular response to tumor necrosis factor; DNA biosynthetic process; extracellular matrix assembly; sphingolipid mediated signaling pathway; dentinogenesis; mitotic nuclear division; cellular response to oxidised low-density lipoprotein particle stimulus; regulation of hyaluronan biosynthetic process; negative regulation of hyaluronan biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	55512
	58994
	ENSG00000103056
	ENSMUSG00000031906
	Q9NY59
	Q9JJY3
	NM_018667
	NM_021491
	NP_061137
	NP_067466
	Wikidata
View/Edit Human	View/Edit Mouse

Sphingomyelin phosphodiesterase 3 is an enzyme that in humans is encoded by the SMPD3 gene.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103056 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031906 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Hofmann K, Tomiuk S, Wolff G, Stoffel W (Jun 2000). "Cloning and characterization of the mammalian brain-specific, Mg2+-dependent neutral sphingomyelinase". Proc Natl Acad Sci U S A. 97 (11): 5895–900. doi:10.1073/pnas.97.11.5895. PMC 18530. PMID 10823942.
^ "Entrez Gene: SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)".

References

Further reading