SPACA3

SPACA3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4YF2
Identifiers
Aliases	SPACA3, 1700025M08Rik, ALLP17, CT54, LYC3, LYZL3, SLLP1, LYZC, sperm acrosome associated 3
External IDs	OMIM: 612749; MGI: 1922872; HomoloGene: 18365; GeneCards: SPACA3; OMA:SPACA3 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	32,997,877 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	80,758,640 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; sperm; ; testicle; ; body of pancreas; ; gonad; ; mucosa of transverse colon; ; right coronary artery; ; tibial nerve; ; granulocyte;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; lacrimal gland; ; morula; ; pancreas; ; cochlea; ; islet of Langerhans; ; foregut; ; stomach;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; lysozyme activity;
Cellular component	integral component of membrane; extracellular region; acrosomal vesicle; secretory granule; membrane; cytoplasmic vesicle; extracellular space; acrosomal membrane; acrosomal matrix;
Biological process	monocyte activation; cell wall macromolecule catabolic process; fertilization; positive regulation of phagocytosis; response to virus; positive regulation of macrophage activation; sperm-egg recognition; defense response to Gram-positive bacterium; peptidoglycan catabolic process; defense response to Gram-negative bacterium; fusion of sperm to egg plasma membrane involved in single fertilization;
	Sources:Amigo / QuickGO
Orthologs
	124912
	75622
	ENSG00000141316
	ENSMUSG00000053184
	Q8IXA5
	Q9D9X8
	NM_173847; NM_001317225; NM_001317226
	NM_029367; NM_001359183
	NP_001304154; NP_001304155; NP_776246
	NP_083643; NP_001346112
	Wikidata
View/Edit Human	View/Edit Mouse

Sperm acrosome membrane-associated protein 3 is a protein that in humans is encoded by the SPACA3 gene. It may be involved in adhesion to the egg before the egg is fertilized.^[5]^[6]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000141316 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053184 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mandal A, Klotz KL, Shetty J, Jayes FL, Wolkowicz MJ, Bolling LC, Coonrod SA, Black MB, Diekman AB, Haystead TA, Flickinger CJ, Herr JC (Apr 2003). "SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa". Biol Reprod. 68 (5): 1525–37. doi:10.1095/biolreprod.102.010108. PMID 12606493.
^ "Entrez Gene: SPACA3 sperm acrosome associated 3".

References

Further reading