SPPL2B

SPPL2B
Identifiers
Aliases	SPPL2B, IMP-4, IMP4, PSH4, PSL1, signal peptide peptidase like 2B
External IDs	OMIM: 608239; MGI: 1920468; HomoloGene: 10605; GeneCards: SPPL2B; OMA:SPPL2B - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	2,355,095 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,704,542 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; anterior pituitary; ; left testis; ; right testis; ; right hemisphere of cerebellum; ; transverse colon; ; right lobe of thyroid gland; ; body of pancreas; ; left lobe of thyroid gland; ; mucosa of transverse colon;
	Top expressed in
	spermatocyte; ; fetal liver hematopoietic progenitor cell; ; spermatid; ; motor neuron; ; saccule; ; neural layer of retina; ; otic vesicle; ; otic placode; ; external carotid artery; ; Rostral migratory stream;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; aspartic-type endopeptidase activity; peptidase activity; protein binding; hydrolase activity; aspartic endopeptidase activity, intramembrane cleaving;
Cellular component	integral component of membrane; endosome; centrosome; Golgi apparatus; membrane; integral component of cytoplasmic side of endoplasmic reticulum membrane; Golgi membrane; nucleoplasm; lysosomal membrane; actin cytoskeleton; Golgi-associated vesicle membrane; lysosome; integral component of lumenal side of endoplasmic reticulum membrane; endosome membrane; plasma membrane;
Biological process	membrane protein proteolysis; proteolysis; membrane protein ectodomain proteolysis; membrane protein intracellular domain proteolysis; regulation of immune response; regulation of tumor necrosis factor-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	56928
	73218
	ENSG00000005206
	ENSMUSG00000035206
	Q8TCT7
	Q3TD49
	NM_001077238; NM_152988
	NM_175195; NM_001358803; NM_001358804
	NP_001070706; NP_694533
	NP_780404; NP_001345732; NP_001345733
	Wikidata
View/Edit Human	View/Edit Mouse

Signal peptide peptidase-like 2B, also known as SPPL2B, is a human gene.^[5]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000005206 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035206 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: SPPL2B signal peptide peptidase-like 2B".

References

Further reading