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Aliases SPRED3, Eve-3, spred-3, sprouty related EVH1 domain containing 3
External IDs MGI: 2142186 HomoloGene: 28061 GeneCards: SPRED3
Gene location (Human)
Chromosome 19 (human)
Chr. Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for SPRED3
Genomic location for SPRED3
Band 19q13.2 Start 38,388,421 bp[1]
End 38,399,587 bp[1]
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 19: 38.39 – 38.4 Mb Chr 19: 29.16 – 29.17 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Sprouty-related, EVH1 domain-containing protein 3 also known as Spread-3 is a protein that in humans is encoded by the SPRED3 gene.[5]

Spread-3 is a member of the Sprouty (see SPRY1/SPRED) family of proteins that regulate growth factor-induced activation of the MAP kinase cascade.[5][6]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000188766 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037239 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ a b "Entrez Gene: sprouty-related". 
  6. ^ Nonami A, Kato R, Taniguchi K, Yoshiga D, Taketomi T, Fukuyama S, Harada M, Sasaki A, Yoshimura A (December 2004). "Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells". The Journal of Biological Chemistry. 279 (50): 52543–51. PMID 15465815. doi:10.1074/jbc.M405189200. 

Further reading[edit]

  • Kato R, Nonami A, Taketomi T, Wakioka T, Kuroiwa A, Matsuda Y, Yoshimura A (March 2003). "Molecular cloning of mammalian Spred-3 which suppresses tyrosine kinase-mediated Erk activation". Biochemical and Biophysical Research Communications. 302 (4): 767–72. PMID 12646235. doi:10.1016/S0006-291X(03)00259-6. 
  • Mizoguchi M, Nutt CL, Louis DN (February 2004). "Mutation analysis of CBL-C and SPRED3 on 19q in human glioblastoma". Neurogenetics. 5 (1): 81–2. PMID 14618415. doi:10.1007/s10048-003-0164-x. 
  • King JA, Corcoran NM, D'Abaco GM, Straffon AF, Smith CT, Poon CL, Buchert M, I S, Hall NE, Lock P, Hovens CM (April 2006). "Eve-3: a liver enriched suppressor of Ras/MAPK signaling". Journal of Hepatology. 44 (4): 758–67. PMID 16478641. doi:10.1016/j.jhep.2005.10.031. 
  • Lock P, I ST, Straffon AF, Schieb H, Hovens CM, Stylli SS (December 2006). "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination". Biochemical and Biophysical Research Communications. 351 (4): 1018–23. PMID 17094949. doi:10.1016/j.bbrc.2006.10.150.