SRGAP3

SRGAP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AM4, 1GRN, 1OW3, 1RGP, 1TX4, 2NGR
Identifiers
Aliases	SRGAP3, ARHGAP14, MEGAP, SRGAP2, WRP, SLIT-ROBO Rho GTPase activating protein 3
External IDs	OMIM: 606525; MGI: 2152938; HomoloGene: 56686; GeneCards: SRGAP3; OMA:SRGAP3 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	9,363,053 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	112,924,227 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; Brodmann area 23; ; paraflocculus of cerebellum; ; Brodmann area 10; ; frontal pole; ; right uterine tube; ; endothelial cell; ; Region I of hippocampus proper; ; Brodmann area 46; ; postcentral gyrus;
	Top expressed in
	subiculum; ; pontine nuclei; ; superior colliculus; ; cingulate gyrus; ; piriform cortex; ; dentate gyrus; ; cerebellar vermis; ; lateral septal nucleus; ; hippocampus proper; ; anterior amygdaloid area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; GTPase activator activity;
Cellular component	cytoplasm; cytosol;
Biological process	negative regulation of cell migration; regulation of small GTPase mediated signal transduction; signal transduction; positive regulation of GTPase activity;
	Sources:Amigo / QuickGO
Orthologs
	9901
	259302
	ENSG00000196220
	ENSMUSG00000030257
	O43295
	Q812A2
	NM_001033116; NM_001033117; NM_014850
	NM_080448; NM_153070
	NP_001028289; NP_055665
	NP_536696
	Wikidata
View/Edit Human	View/Edit Mouse

SLIT-ROBO Rho GTPase-activating protein 3 is an enzyme that in humans is encoded by the SRGAP3 gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196220 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030257 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Endris V, Wogatzky B, Leimer U, Bartsch D, Zatyka M, Latif F, Maher ER, Tariverdian G, Kirsch S, Karch D, Rappold GA (Sep 2002). "The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation". Proc Natl Acad Sci U S A. 99 (18): 11754–9. doi:10.1073/pnas.162241099. PMC 129341. PMID 12195014.
^ "Entrez Gene: SRGAP3 SLIT-ROBO Rho GTPase activating protein 3".