SSX1

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SSX1
Identifiers
AliasesSSX1, CT5.1, SSRC, synovial sarcoma, X breakpoint 1, SSX family member 1
External IDsHomoloGene: 136735 GeneCards: SSX1
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for SSX1
Genomic location for SSX1
BandXp11.23Start48,255,317 bp[1]
End48,267,444 bp[1]
RNA expression pattern
PBB GE SSX1 206627 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005635
NM_001278691

n/a

RefSeq (protein)

NP_001265620
NP_005626

n/a

Location (UCSC)Chr X: 48.26 – 48.27 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Protein SSX1 is a protein that in humans is encoded by the SSX1 gene.[3][4]

The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity.[4]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000126752 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". 
  3. ^ de Leeuw B, Balemans M, Olde Weghuis D, Geurts van Kessel A (Oct 1995). "Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas". Hum Mol Genet. 4 (6): 1097–9. doi:10.1093/hmg/4.6.1097. PMID 7655467. 
  4. ^ a b "Entrez Gene: SSX1 synovial sarcoma, X breakpoint 1". 

Further reading[edit]