SSX1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SSX1
Identifiers
Aliases SSX1, CT5.1, SSRC, synovial sarcoma, X breakpoint 1
External IDs HomoloGene: 136735 GeneCards: 6756
RNA expression pattern
PBB GE SSX1 206626 x at tn.png

PBB GE SSX1 206627 s at tn.png

PBB GE SSX1 210394 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005635
NM_001278691

n/a

RefSeq (protein)

NP_001265620.1
NP_005626.1

n/a

Location (UCSC) Chr X: 48.26 – 48.27 Mb n/a
PubMed search [1] n/a
Wikidata
View/Edit Human

Protein SSX1 is a protein that in humans is encoded by the SSX1 gene.[2][3]

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity.[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ de Leeuw B, Balemans M, Olde Weghuis D, Geurts van Kessel A (Oct 1995). "Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas". Hum Mol Genet. 4 (6): 1097–9. doi:10.1093/hmg/4.6.1097. PMID 7655467. 
  3. ^ a b "Entrez Gene: SSX1 synovial sarcoma, X breakpoint 1". 

Further reading[edit]