SSX2

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SSX2B
Identifiers
AliasesSSX2B, CT5.2, CT5.2b, HOM-MEL-40, SSX, synovial sarcoma, X breakpoint 2B, SSX family member 2B
External IDsHomoloGene: 133226 GeneCards: SSX2B
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for SSX2B
Genomic location for SSX2B
BandXp11.22Start52,751,132 bp[1]
End52,790,305 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001278702
NM_001164417
NM_001278701

n/a

RefSeq (protein)

NP_001157889
NP_001265630
NP_001265631

n/a

Location (UCSC)Chr X: 52.75 – 52.79 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

Protein SSX2 is a protein that in humans is encoded by the SSX2 gene.[3][4]

The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms have been identified for this gene.[4]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000268447 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ Tureci O, Sahin U, Schobert I, Koslowski M, Scmitt H, Schild HJ, Stenner F, Seitz G, Rammensee HG, Pfreundschuh M (Nov 1996). "The SSX-2 gene, which is involved in the t(X;18) translocation of synovial sarcomas, codes for the human tumor antigen HOM-MEL-40". Cancer Res. 56 (20): 4766–72. PMID 8840996.
  4. ^ a b "Entrez Gene: SSX2 synovial sarcoma, X breakpoint 2".

Further reading[edit]