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AliasesSSX2, CT5.2, CT5.2A, HD21, HOM-MEL-40, SSX, synovial sarcoma, X breakpoint 2, SSX family member 2
External IDsHomoloGene: 133226 GeneCards: SSX2
Gene location (Human)
X chromosome (human)
Chr.X chromosome (human)[1]
X chromosome (human)
Genomic location for SSX2
Genomic location for SSX2
BandXp11.22Start52,696,896 bp[1]
End52,707,189 bp[1]
RNA expression pattern
PBB GE SSX2 207666 x at fs.png

PBB GE SSX1 206626 x at fs.png

PBB GE SSX1 210394 x at fs.png
More reference expression data
RefSeq (mRNA)



RefSeq (protein)


Location (UCSC)Chr X: 52.7 – 52.71 Mbn/a
PubMed search[2]n/a
View/Edit Human

Protein SSX2 is a protein that in humans is encoded by the SSX2 gene.[3][4]

The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms have been identified for this gene.[4]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000241476 - Ensembl, May 2017
  2. ^ "Human PubMed Reference:".
  3. ^ Tureci O, Sahin U, Schobert I, Koslowski M, Scmitt H, Schild HJ, Stenner F, Seitz G, Rammensee HG, Pfreundschuh M (Nov 1996). "The SSX-2 gene, which is involved in the t(X;18) translocation of synovial sarcomas, codes for the human tumor antigen HOM-MEL-40". Cancer Res. 56 (20): 4766–72. PMID 8840996.
  4. ^ a b "Entrez Gene: SSX2 synovial sarcoma, X breakpoint 2".

Further reading[edit]