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Synovial sarcoma, X breakpoint 2
Symbols SSX2 ; CT5.2; CT5.2A; HD21; HOM-MEL-40; SSX
External IDs OMIM300192 HomoloGene133226 GeneCards: SSX2 Gene
RNA expression pattern
PBB GE SSX2 207666 x at tn.png
PBB GE SSX1 206626 x at tn.png
PBB GE SSX1 210394 x at tn.png
More reference expression data
Species Human Mouse
Entrez 6757 67985
Ensembl ENSG00000241476 ENSMUSG00000079705
UniProt Q16385 Q9CPU1
RefSeq (mRNA) NM_001278697 NM_026492.3
RefSeq (protein) NP_001265626 NP_080768.1
Location (UCSC) Chr X:
52.64 – 52.71 Mb
Chr X:
8.41 – 8.42 Mb
PubMed search [1] [2]

Protein SSX2 is a protein that in humans is encoded by the SSX2 gene.[1][2]

The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms have been identified for this gene.[2]


  1. ^ Tureci O, Sahin U, Schobert I, Koslowski M, Scmitt H, Schild HJ, Stenner F, Seitz G, Rammensee HG, Pfreundschuh M (Nov 1996). "The SSX-2 gene, which is involved in the t(X;18) translocation of synovial sarcomas, codes for the human tumor antigen HOM-MEL-40". Cancer Res 56 (20): 4766–72. PMID 8840996. 
  2. ^ a b "Entrez Gene: SSX2 synovial sarcoma, X breakpoint 2". 

Further reading[edit]