ST3GAL5

ST3GAL5
Identifiers
Aliases	ST3GAL5, SATI, SIAT9, SIATGM3S, ST3GalV, ST3 beta-galactoside alpha-2,3-sialyltransferase 5, SPDRS, ST3Gal V
External IDs	OMIM: 604402; MGI: 1339963; HomoloGene: 2893; GeneCards: ST3GAL5; OMA:ST3GAL5 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	85,905,199 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	72,131,555 bp
RNA expression pattern
	Top expressed in
	right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; left adrenal cortex; ; C1 segment; ; lateral nuclear group of thalamus; ; decidua; ; middle temporal gyrus;
	Top expressed in
	granulocyte; ; fetal liver hematopoietic progenitor cell; ; adrenal gland; ; soleus muscle; ; blood; ; tibiofemoral joint; ; choroid plexus of fourth ventricle; ; superior frontal gyrus; ; epithelium of lens; ; temporal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; lactosylceramide alpha-2,3-sialyltransferase activity; glycosyltransferase activity; neolactotetraosylceramide alpha-2,3-sialyltransferase activity; sialyltransferase activity; beta-galactoside (CMP) alpha-2,3-sialyltransferase activity;
Cellular component	integral component of membrane; Golgi apparatus; membrane; integral component of plasma membrane; Golgi membrane;
Biological process	glycosphingolipid biosynthetic process; protein glycosylation; oligosaccharide metabolic process; sialylation; protein N-linked glycosylation via asparagine; ganglioside biosynthetic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	8869
	20454
	ENSG00000115525
	ENSMUSG00000056091
	Q9UNP4
	O88829
NM_001042437; NM_003896; NM_001354226; NM_001354227; NM_001354233;
	NM_001354234; NM_001354238; NM_001354247; NM_001354248; NM_001354223; NM_001354224; NM_001354229; NM_001363847
	NM_001035228; NM_011375
NP_001035902; NP_003887; NP_001341155; NP_001341156; NP_001341162;
	NP_001341163; NP_001341167; NP_001341176; NP_001341177; NP_001341152; NP_001341153; NP_001341158; NP_001350776
	NP_001030305; NP_035505
	Wikidata
View/Edit Human	View/Edit Mouse

Lactosylceramide alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL5 gene.^[5]^[6]

Template:PBB Summary

Mutations in this gene have also been associated to ‘Salt & Pepper’ syndrome: an autosomal recessive condition characterized by severe intellectual disability, epilepsy, scoliosis, choreoathetosis, dysmorphic facial features and altered dermal pigmentation. (doi: 10.1093/hmg/ddt434)

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000115525 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056091 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ishii A, Ohta M, Watanabe Y, Matsuda K, Ishiyama K, Sakoe K, Nakamura M, Inokuchi J, Sanai Y, Saito M (Dec 1998). "Expression cloning and functional characterization of human cDNA for ganglioside GM3 synthase". J Biol Chem. 273 (48): 31652–5. doi:10.1074/jbc.273.48.31652. PMID 9822625.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5".

References

Further reading