ST6GAL1

From Wikipedia, the free encyclopedia
Jump to: navigation, search
ST6GAL1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ST6GAL1, SIAT1, ST6GalI, ST6N, ST6 beta-galactoside alpha-2,6-sialyltransferase 1
External IDs MGI: 108470 HomoloGene: 2281 GeneCards: ST6GAL1
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003032
NM_173216
NM_173217

NM_001252505
NM_001252506
NM_145933

RefSeq (protein)

NP_003023
NP_775323
NP_775324

NP_001239434
NP_001239435
NP_666045

Location (UCSC) Chr 3: 186.93 – 187.08 Mb Chr 16: 23.22 – 23.36 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Beta-galactoside alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GAL1 gene.[3]

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein, which is normally found in the Golgi but which can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76. This protein is a member of glycosyltransferase family 29. Three transcript variants encoding two different isoforms have been found for this gene.[4]

Transcripts of ST6GAL1 are found in mouse high endothelial cells of mesenteric lymph node and Peyer's patches, and it could be involved in the B cell homing to Peyer's patches.[5]

References[edit]

Further reading[edit]