ST6GAL1

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ST6GAL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesST6GAL1, SIAT1, ST6GalI, ST6N, ST6 beta-galactoside alpha-2,6-sialyltransferase 1
External IDsMGI: 108470 HomoloGene: 2281 GeneCards: ST6GAL1
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for ST6GAL1
Genomic location for ST6GAL1
Band3q27.3Start186,930,485 bp[1]
End187,078,553 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003032
NM_173216
NM_173217
NM_001353916

NM_001252505
NM_001252506
NM_145933

RefSeq (protein)

NP_003023
NP_775323
NP_775324
NP_001340845

NP_001239434
NP_001239435
NP_666045

Location (UCSC)Chr 3: 186.93 – 187.08 MbChr 16: 23.22 – 23.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Beta-galactoside alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GAL1 gene.[5]

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein, which is normally found in the Golgi but which can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CDw75, and CD76. This protein is a member of glycosyltransferase family 29. Three transcript variants encoding two different isoforms have been found for this gene.[6]

Transcripts of ST6GAL1 are found in mouse high endothelial cells of mesenteric lymph node and Peyer's patches, and it could be involved in the B cell homing to Peyer's patches.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000073849 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022885 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ Grundmann U, Nerlich C, Rein T, Zettlmeissl G (Apr 1990). "Complete cDNA sequence encoding human beta-galactoside alpha-2,6-sialyltransferase". Nucleic Acids Res. 18 (3): 667. doi:10.1093/nar/18.3.667. PMC 333489. PMID 2408023.
  6. ^ "Entrez Gene: ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1".
  7. ^ Lee; et al. (Oct 2014). "Transcriptional programs of lymphoid tissue capillary and high endothelium reveal control mechanisms for lymphocyte homing". Nature Immunology. 15 (10): 982–995. doi:10.1038/ni.2983. PMC 4222088. PMID 25173345.

Further reading[edit]