ST7

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See also ST6/ST7 microcontroller

ST7
Identifiers
Aliases ST7, ETS7q, FAM4A, FAM4A1, HELG, RAY1, SEN4, TSG7, suppression of tumorigenicity 7
External IDs MGI: 1927450 HomoloGene: 10185 GeneCards: ST7
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021908
NM_018412

RefSeq (protein)

NP_060882
NP_068708

Location (UCSC) Chr 7: 116.95 – 117.23 Mb Chr 6: 17.69 – 17.94 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Suppressor of tumorigenicity protein 7 is a protein that in humans is encoded by the ST7 gene.[3][4][5] ST7 orthologs [6] have been identified in all mammals for which complete genome data are available.

Function[edit]

The gene for this product maps to a region on human chromosome 7 identified as an autism-susceptibility locus. Mutation screening of the entire coding region in autistic individuals failed to identify phenotype-specific variants, suggesting that coding mutations for this gene are unlikely to be involved in the etiology of autism. The function of this gene product has not been determined. Transcript variants encoding different isoforms of this protein have been described.[5]

Interactions[edit]

ST7 has been shown to interact with ITGB1BP3[7] and GNB2L1.[7]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Ogata T, Ayusawa D, Namba M, Takahashi E, Oshimura M, Oishi M (October 1993). "Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1". Molecular and Cellular Biology. 13 (10): 6036–43. doi:10.1128/mcb.13.10.6036. PMC 364663Freely accessible. PMID 8105370. 
  4. ^ Zenklusen JC, Rodriguez LV, LaCava M, Wang Z, Goldstein LS, Conti CJ (November 1996). "Novel susceptibility locus for mouse hepatomas: evidence for a conserved tumor suppressor gene". Genome Research. 6 (11): 1070–6. doi:10.1101/gr.6.11.1070. PMID 8938430. 
  5. ^ a b "Entrez Gene: ST7 suppression of tumorigenicity 7". 
  6. ^ "OrthoMaM phylogenetic marker: ST7 coding sequence". 
  7. ^ a b Battle MA, Maher VM, McCormick JJ (June 2003). "ST7 is a novel low-density lipoprotein receptor-related protein (LRP) with a cytoplasmic tail that interacts with proteins related to signal transduction pathways". Biochemistry. 42 (24): 7270–82. doi:10.1021/bi034081y. PMID 12809483. 

Further reading[edit]