STXBP1

STXBP1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3PUJ
Identifiers
Aliases	STXBP1, MUNC18-1, NSEC1, P67, RBSEC1, UNC18, syntaxin binding protein 1
External IDs	OMIM: 602926; MGI: 107363; HomoloGene: 2382; GeneCards: STXBP1; OMA:STXBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	127,696,027 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	32,737,257 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; lateral nuclear group of thalamus; ; Brodmann area 23; ; pons; ; superior frontal gyrus; ; primary visual cortex; ; right hemisphere of cerebellum; ; pars compacta; ; postcentral gyrus; ; paraflocculus of cerebellum;
	Top expressed in
	neural layer of retina; ; pontine nuclei; ; inferior colliculi; ; perirhinal cortex; ; superior colliculus; ; central gray substance of midbrain; ; piriform cortex; ; medulla oblongata; ; cerebellar cortex; ; medial vestibular nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; protein N-terminus binding; syntaxin-1 binding; protein binding; identical protein binding; syntaxin binding; protein kinase binding; SNARE binding; RNA binding; phospholipase binding;
Cellular component	platelet alpha granule; membrane; myelin sheath; plasma membrane; nucleoplasm; terminal bouton; mitochondrion; extracellular exosome; cytoplasm; cytosol; presynaptic active zone membrane; nucleus; cytoskeleton; axon; perinuclear region of cytoplasm; presynapse; postsynapse; protein-containing complex; phagocytic vesicle; glutamatergic synapse;
Biological process	negative regulation of neuron apoptotic process; exocytosis; axon target recognition; protein stabilization; platelet degranulation; positive regulation of calcium ion-dependent exocytosis; glutamate secretion; regulation of synaptic vesicle fusion to presynaptic active zone membrane; neuromuscular synaptic transmission; negative regulation of synaptic transmission, GABAergic; long-term depression; protein transport; positive regulation of exocytosis; protein localization to plasma membrane; platelet aggregation; regulation of SNARE complex assembly; synaptic vesicle maturation; vesicle-mediated transport; neurotransmitter secretion; regulation of synaptic vesicle priming; vesicle docking involved in exocytosis; negative regulation of protein-containing complex assembly; presynaptic dense core vesicle exocytosis; developmental process involved in reproduction; regulation of vesicle fusion; response to estradiol; positive regulation of mast cell degranulation; positive regulation of vesicle docking; positive regulation of glutamate secretion, neurotransmission; transport; synaptic vesicle priming; cellular response to interferon-gamma; SNARE complex assembly; regulation of acrosomal vesicle exocytosis;
	Sources:Amigo / QuickGO
Orthologs
	6812
	20910
	ENSG00000136854
	ENSMUSG00000026797
	P61764
	O08599
	NM_003165; NM_001032221
	NM_001113569; NM_009295
NP_001027392; NP_003156; NP_001361235; NP_001361236; NP_001361237;
	NP_001361238; NP_001361239; NP_001361240; NP_001361241; NP_001361242; NP_001361243; NP_001361244
	NP_001107041; NP_033321
	Wikidata
View/Edit Human	View/Edit Mouse

Syntaxin-binding protein 1 is a protein that in humans is encoded by the STXBP1 gene.^[5]^[6]

In melanocytic cells STXBP1 gene expression may be regulated by MITF.^[7]

Interactions

STXBP1 has been shown to interact with STX2,^[8]^[9] STX4^[8]^[9] and STX1A.^[9]^[10]^[11]^[12]^[13]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000136854 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026797 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Swanson DA, Steel JM, Valle D (Jun 1998). "Identification and characterization of the human ortholog of rat STXBP1, a protein implicated in vesicle trafficking and neurotransmitter release". Genomics. 48 (3): 373–6. doi:10.1006/geno.1997.5202. PMID 9545644.
^ "Entrez Gene: STXBP1 syntaxin binding protein 1".
^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
^ ^a ^b Schraw TD, Lemons PP, Dean WL, Whiteheart SW (Aug 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". Biochem. J. 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. PMC 1223584. PMID 12773094.
^ ^a ^b ^c Hata Y, Südhof TC (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Bhaskar K, Shareef MM, Sharma VM, Shetty AP, Ramamohan Y, Pant HC, Raju TR, Shetty KT (Jan 2004). "Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins". Neurochem. Int. 44 (1): 35–44. doi:10.1016/S0197-0186(03)00099-8. PMID 12963086.
^ Dulubova I, Sugita S, Hill S, Hosaka M, Fernandez I, Südhof TC, Rizo J (Aug 1999). "A conformational switch in syntaxin during exocytosis: role of munc18". EMBO J. 18 (16): 4372–82. doi:10.1093/emboj/18.16.4372. PMC 1171512. PMID 10449403.
^ McMahon HT, Missler M, Li C, Südhof TC (Oct 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell. 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862.
^ Pérez-Brangulí F, Muhaisen A, Blasi J (Jun 2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay". Mol. Cell. Neurosci. 20 (2): 169–80. doi:10.1006/mcne.2002.1122. PMID 12093152.

Garcia EP, McPherson PS, Chilcote TJ, Takei K, De Camilli P (1995). "rbSec1A and B colocalize with syntaxin 1 and SNAP-25 throughout the axon, but are not in a stable complex with syntaxin". J. Cell Biol. 129 (1): 105–20. doi:10.1083/jcb.129.1.105. PMC 2120371. PMID 7698978.
Pevsner J, Hsu SC, Scheller RH (1994). "n-Sec1: a neural-specific syntaxin-binding protein". Proc. Natl. Acad. Sci. U.S.A. 91 (4): 1445–9. doi:10.1073/pnas.91.4.1445. PMC 43176. PMID 8108429.
Fujita Y, Sasaki T, Fukui K, Kotani H, Kimura T, Hata Y, Südhof TC, Scheller RH, Takai Y (1996). "Phosphorylation of Munc-18/n-Sec1/rbSec1 by protein kinase C: its implication in regulating the interaction of Munc-18/n-Sec1/rbSec1 with syntaxin". J. Biol. Chem. 271 (13): 7265–8. doi:10.1074/jbc.271.13.7265. PMID 8631738.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Gengyo-Ando K, Kitayama H, Mukaida M, Ikawa Y (1996). "A murine neural-specific homolog corrects cholinergic defects in Caenorhabditis elegans unc-18 mutants". J. Neurosci. 16 (21): 6695–702. PMID 8824310.
Tellam JT, Macaulay SL, McIntosh S, Hewish DR, Ward CW, James DE (1997). "Characterization of Munc-18c and syntaxin-4 in 3T3-L1 adipocytes. Putative role in insulin-dependent movement of GLUT-4". J. Biol. Chem. 272 (10): 6179–86. doi:10.1074/jbc.272.10.6179. PMID 9045631.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Verhage M, de Vries KJ, Røshol H, Burbach JP, Gispen WH, Südhof TC (1997). "DOC2 proteins in rat brain: complementary distribution and proposed function as vesicular adapter proteins in early stages of secretion". Neuron. 18 (3): 453–61. doi:10.1016/S0896-6273(00)81245-3. PMID 9115738.
Okamoto M, Südhof TC (1997). "Mints, Munc18-interacting proteins in synaptic vesicle exocytosis". J. Biol. Chem. 272 (50): 31459–64. doi:10.1074/jbc.272.50.31459. PMID 9395480.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Fletcher AI, Shuang R, Giovannucci DR, Zhang L, Bittner MA, Stuenkel EL (1999). "Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18". J. Biol. Chem. 274 (7): 4027–35. doi:10.1074/jbc.274.7.4027. PMID 9933594.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Reed GL, Houng AK, Fitzgerald ML (1999). "Human platelets contain SNARE proteins and a Sec1p homologue that interacts with syntaxin 4 and is phosphorylated after thrombin activation: implications for platelet secretion". Blood. 93 (8): 2617–26. PMID 10194441.
Dulubova I, Sugita S, Hill S, Hosaka M, Fernandez I, Südhof TC, Rizo J (1999). "A conformational switch in syntaxin during exocytosis: role of munc18". EMBO J. 18 (16): 4372–82. doi:10.1093/emboj/18.16.4372. PMC 1171512. PMID 10449403.
Misura KM, Scheller RH, Weis WI (2000). "Three-dimensional structure of the neuronal-Sec1-syntaxin 1a complex". Nature. 404 (6776): 355–62. doi:10.1038/35006120. PMID 10746715.
Allan BB, Moyer BD, Balch WE (2000). "Rab1 recruitment of p115 into a cis-SNARE complex: programming budding COPII vesicles for fusion". Science. 289 (5478): 444–8. doi:10.1126/science.289.5478.444. PMID 10903204.
Shorter J, Beard MB, Seemann J, Dirac-Svejstrup AB, Warren G (2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMC 2173270. PMID 11927603.
Ho CS, Marinescu V, Steinhilb ML, Gaut JR, Turner RS, Stuenkel EL (2002). "Synergistic effects of Munc18a and X11 proteins on amyloid precursor protein metabolism". J. Biol. Chem. 277 (30): 27021–8. doi:10.1074/jbc.M201823200. PMID 12016213.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Pérez-Brangulí F, Muhaisen A, Blasi J (2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay". Mol. Cell. Neurosci. 20 (2): 169–80. doi:10.1006/mcne.2002.1122. PMID 12093152.
Barclay JW, Craig TJ, Fisher RJ, Ciufo LF, Evans GJ, Morgan A, Burgoyne RD (2003). "Phosphorylation of Munc18 by protein kinase C regulates the kinetics of exocytosis". J. Biol. Chem. 278 (12): 10538–45. doi:10.1074/jbc.M211114200. PMID 12519779.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Fukuda M (2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". J. Biol. Chem. 278 (17): 15390–6. doi:10.1074/jbc.M213090200. PMID 12590134.{{cite journal}}: CS1 maint: unflagged free DOI (link)
Craig TJ, Evans GJ, Morgan A (2003). "Physiological regulation of Munc18/nSec1 phosphorylation on serine-313". J. Neurochem. 86 (6): 1450–7. doi:10.1046/j.1471-4159.2003.01955.x. PMID 12950453.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000136854 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026797 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9545644-5] Swanson DA, Steel JM, Valle D (Jun 1998). "Identification and characterization of the human ortholog of rat STXBP1, a protein implicated in vesicle trafficking and neurotransmitter release". Genomics. 48 (3): 373–6. doi:10.1006/geno.1997.5202. PMID 9545644.

[entrez-6] "Entrez Gene: STXBP1 syntaxin binding protein 1".

[pmid19067971-7] Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

[pmid12773094-8] Schraw TD, Lemons PP, Dean WL, Whiteheart SW (Aug 2003). "A role for Sec1/Munc18 proteins in platelet exocytosis". Biochem. J. 374 (Pt 1): 207–17. doi:10.1042/BJ20030610. PMC 1223584. PMID 12773094.

[pmid7768895-9] Hata Y, Südhof TC (Jun 1995). "A novel ubiquitous form of Munc-18 interacts with multiple syntaxins. Use of the yeast two-hybrid system to study interactions between proteins involved in membrane traffic". J. Biol. Chem. 270 (22): 13022–8. doi:10.1074/jbc.270.22.13022. PMID 7768895.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[pmid12963086-10] Bhaskar K, Shareef MM, Sharma VM, Shetty AP, Ramamohan Y, Pant HC, Raju TR, Shetty KT (Jan 2004). "Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins". Neurochem. Int. 44 (1): 35–44. doi:10.1016/S0197-0186(03)00099-8. PMID 12963086.

[pmid10449403-11] Dulubova I, Sugita S, Hill S, Hosaka M, Fernandez I, Südhof TC, Rizo J (Aug 1999). "A conformational switch in syntaxin during exocytosis: role of munc18". EMBO J. 18 (16): 4372–82. doi:10.1093/emboj/18.16.4372. PMC 1171512. PMID 10449403.

[pmid7553862-12] McMahon HT, Missler M, Li C, Südhof TC (Oct 1995). "Complexins: cytosolic proteins that regulate SNAP receptor function". Cell. 83 (1): 111–9. doi:10.1016/0092-8674(95)90239-2. PMID 7553862.

[pmid12093152-13] Pérez-Brangulí F, Muhaisen A, Blasi J (Jun 2002). "Munc 18a binding to syntaxin 1A and 1B isoforms defines its localization at the plasma membrane and blocks SNARE assembly in a three-hybrid system assay". Mol. Cell. Neurosci. 20 (2): 169–80. doi:10.1006/mcne.2002.1122. PMID 12093152.

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Interactions

References

Further reading