SULF2

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SULF2
Identifiers
Aliases SULF2, HSULF-2, sulfatase 2
External IDs MGI: 1919293 HomoloGene: 10313 GeneCards: SULF2
Genetically Related Diseases
attention deficit hyperactivity disorder[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001161841
NM_018837
NM_198596

NM_001252578
NM_001252579
NM_028072

RefSeq (protein)

NP_001155313
NP_061325
NP_940998

Location (UCSC) Chr 20: 47.66 – 47.79 Mb Chr 2: 166.07 – 166.16 Mb
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Extracellular sulfatase Sulf-2 is an enzyme that in humans is encoded by the SULF2 gene.[4][5]

Function[edit]

Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005).[supplied by OMIM][5]

References[edit]

Further reading[edit]