SULT1C3

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SULT1C3
PDB 2h8k EBI.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SULT1C3, ST1C3, sulfotransferase family 1C member 3
External IDs MGI: 102928 HomoloGene: 56817 GeneCards: SULT1C3
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001008743
NM_001320878

NM_018751

RefSeq (protein)

NP_001008743
NP_001307807

NP_061221.2
NP_061221

Location (UCSC) Chr 2: 108.25 – 108.27 Mb Chr 17: 53.96 – 53.99 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Sulfotransferase 1C3, also known as ST1C3, is an enzyme that in humans is encoded by the SULT1C3 gene.[3][4][5]

Function[edit]

Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members.[3]

Clinical significance[edit]

ST1C3 sulfates large benzylic alcohols such as 1-hydroxymethyl-pyrene to chemically reactive mutagenic sulpho conjugates.[6]

See also[edit]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: sulfotransferase family". 
  4. ^ Freimuth RR, Wiepert M, Chute CG, Wieben ED, Weinshilboum RM (2004). "Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes". Pharmacogenomics J. 4 (1): 54–65. doi:10.1038/sj.tpj.6500223. PMID 14676822. 
  5. ^ Allali-Hassani A, Pan PW, Dombrovski L, Najmanovich R, Tempel W, Dong A, Loppnau P, Martin F, Thornton J, Thonton J, Edwards AM, Bochkarev A, Plotnikov AN, Vedadi M, Arrowsmith CH (May 2007). "Structural and chemical profiling of the human cytosolic sulfotransferases". PLoS Biol. 5 (5): e97. doi:10.1371/journal.pbio.0050097. PMC 1847840Freely accessible. PMID 17425406. 
  6. ^ Meinl W, Donath C, Schneider H, Sommer Y, Glatt H (April 2008). "SULT1C3, an orphan sequence of the human genome, encodes an enzyme activating various promutagens". Food Chem. Toxicol. 46 (4): 1249–56. doi:10.1016/j.fct.2007.08.040. PMID 17936463.