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Synaptic vesicle glycoprotein 2A
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols SV2A ; SV2
External IDs OMIM185860 MGI1927139 HomoloGene32237 ChEMBL: 1998 GeneCards: SV2A Gene
RNA expression pattern
PBB GE SV2A 203069 at tn.png
More reference expression data
Species Human Mouse
Entrez 9900 64051
Ensembl ENSG00000159164 ENSMUSG00000038486
UniProt Q7L0J3 Q9JIS5
RefSeq (mRNA) NM_001278719 NM_022030
RefSeq (protein) NP_001265648 NP_071313
Location (UCSC) Chr 1:
149.9 – 149.92 Mb
Chr 3:
96.18 – 96.2 Mb
PubMed search [1] [2]

Synaptic vesicle glycoprotein 2A is a ubiquitous synaptic vesicle protein that in humans is encoded by the SV2A gene.[1][2][3] The protein is targeted by the anti-epileptic drugs (anticonvulsants) levetiracetam and brivaracetam.[4]

See also[edit]


  1. ^ Bajjalieh SM, Peterson K, Linial M, Scheller RH (Mar 1993). "Brain contains two forms of synaptic vesicle protein 2". Proceedings of the National Academy of Sciences of the United States of America 90 (6): 2150–4. doi:10.1073/pnas.90.6.2150. PMC 46043. PMID 7681585. 
  2. ^ Crowder KM, Gunther JM, Jones TA, Hale BD, Zhang HZ, Peterson MR, Scheller RH, Chavkin C, Bajjalieh SM (Dec 1999). "Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A)". Proceedings of the National Academy of Sciences of the United States of America 96 (26): 15268–73. doi:10.1073/pnas.96.26.15268. PMC 24809. PMID 10611374. 
  3. ^ "Entrez Gene: SV2A synaptic vesicle glycoprotein 2A". 
  4. ^ Ulloa CM, Towfigh A, Safdieh J (2009). "Review of levetiracetam, with a focus on the extended release formulation, as adjuvant therapy in controlling partial-onset seizures". Neuropsychiatric Disease and Treatment 5: 467–76. doi:10.2147/ndt.s4844. PMC 2747386. PMID 19777068. 

Further reading[edit]