SYTL1

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SYTL1
Identifiers
Aliases SYTL1, JFC1, SLP1, synaptotagmin like 1
External IDs MGI: 1933365 HomoloGene: 12853 GeneCards: 84958
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001193308
NM_032872

NM_031393

RefSeq (protein)

NP_001180237.1
NP_116261.1

n/a

Location (UCSC) Chr 1: 27.34 – 27.35 Mb Chr 4: 133.25 – 133.26 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Synaptotagmin-like protein 1 is a protein that in humans is encoded by the SYTL1 gene.[1][2]


Model organisms[edit]

Model organisms have been used in the study of SYTL1 function. A conditional knockout mouse line, called Sytl1tm1a(KOMP)Wtsi[11][12] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[13][14][15]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[9][16] Twenty four tests were carried out on homozygous mutant mice and six significant abnormalities were observed.[9] Females had abnormal locomotor coordination, caudal vertebral transformation, decreased circulating amylase levels and increased mean platelet volume. Both sexes displayed decreased IgG2b levels and abnormal peripheral blood lymphocyte parameters.[9]

Interactions[edit]

SYTL1 has been shown to interact with RAB27A.[17][18][19]

References[edit]

  1. ^ Catz SD, Babior BM, Johnson JL (November 2002). "JFC1 is transcriptionally activated by nuclear factor-kappaB and up-regulated by tumour necrosis factor alpha in prostate carcinoma cells". The Biochemical Journal 367 (Pt 3): 791–9. doi:10.1042/BJ20020345. PMC 1222920. PMID 12137562. 
  2. ^ "Entrez Gene: SYTL1 synaptotagmin-like 1". 
  3. ^ "Radiography data for Sytl1". Wellcome Trust Sanger Institute. 
  4. ^ "Clinical chemistry data for Sytl1". Wellcome Trust Sanger Institute. 
  5. ^ "Haematology data for Sytl1". Wellcome Trust Sanger Institute. 
  6. ^ "Peripheral blood lymphocytes data for Sytl1". Wellcome Trust Sanger Institute. 
  7. ^ "Salmonella infection data for Sytl1". Wellcome Trust Sanger Institute. 
  8. ^ "Citrobacter infection data for Sytl1". Wellcome Trust Sanger Institute. 
  9. ^ a b c d Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x. 
  10. ^ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  11. ^ "International Knockout Mouse Consortium". 
  12. ^ "Mouse Genome Informatics". 
  13. ^ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (June 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750. 
  14. ^ Dolgin E (June 2011). "Mouse library set to be knockout". Nature 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718. 
  15. ^ Collins FS, Rossant J, Wurst W (January 2007). "A mouse for all reasons". Cell 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247. 
  16. ^ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353. 
  17. ^ Fukuda M (April 2003). "Slp4-a/granuphilin-a inhibits dense-core vesicle exocytosis through interaction with the GDP-bound form of Rab27A in PC12 cells". The Journal of Biological Chemistry 278 (17): 15390–6. doi:10.1074/jbc.M213090200. PMID 12590134. 
  18. ^ Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC (July 2002). "A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport". The Journal of Biological Chemistry 277 (28): 25423–30. doi:10.1074/jbc.M202574200. PMID 11980908. 
  19. ^ Kuroda TS, Fukuda M, Ariga H, Mikoshiba K (March 2002). "The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain". The Journal of Biological Chemistry 277 (11): 9212–8. doi:10.1074/jbc.M112414200. PMID 11773082. 

Further reading[edit]