Sec61

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Identifiers
SymbolSecY
PfamPF00344
TCDB3.A.5
OPM superfamily19
OPM protein2wwb
Membranome165

Sec61 is an endoplasmic reticulum (ER) membrane protein translocator (aka translocon). It is a doughnut-shaped pore through the membrane with 3 major subunits (heterotrimeric). It has a region called the plug that blocks transport into or out of the ER. This plug is displaced when the hydrophobic region of a nascent polypeptide interacts with another region of Sec61 called the seam, allowing translocation of the polypeptide into the ER lumen.

Human proteins[edit]

References[edit]

  • Alberts, Bruce et al. Molecular Biology of the Cell. Garland, 2002. ISBN 0-8153-3218-1

External links[edit]