SEC61B

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SEC61B
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SEC61B, Sec61 translocon beta subunit
External IDs MGI: 1913462 HomoloGene: 38229 GeneCards: SEC61B
RNA expression pattern
PBB GE SEC61B 203133 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006808

NM_024171

RefSeq (protein)

NP_006799

NP_077133.1
NP_077133

Location (UCSC) Chr 9: 99.22 – 99.23 Mb Chr 4: 47.47 – 47.48 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene.[3][4][5]

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.[5]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Hartmann E, Sommer T, Prehn S, Gorlich D, Jentsch S, Rapoport TA (Mar 1994). "Evolutionary conservation of components of the protein translocation complex". Nature. 367 (6464): 654–7. doi:10.1038/367654a0. PMID 8107851. 
  4. ^ Greenfield JJ, High S (Aug 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". J Cell Sci. 112 (10): 1477–86. PMID 10212142. 
  5. ^ a b "Entrez Gene: SEC61B Sec61 beta subunit". 

Further reading[edit]