Plunc

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BPIFA1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases BPIFA1, LUNX, NASG, PLUNC, SPLUNC1, SPURT, bA49G10.5, BPI fold containing family A member 1
External IDs OMIM: 607412 MGI: 1338036 HomoloGene: 7895 GeneCards: BPIFA1
Gene location (Human)
Chromosome 20 (human)
Chr. Chromosome 20 (human)[1]
Chromosome 20 (human)
Genomic location for BPIFA1
Genomic location for BPIFA1
Band 20q11.21 Start 33,235,995 bp[1]
End 33,243,311 bp[1]
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001243193
NM_016583
NM_130852

NM_011126

RefSeq (protein)

NP_001230122
NP_057667
NP_570913

NP_035256

Location (UCSC) Chr 20: 33.24 – 33.24 Mb Chr 20: 154.14 – 154.15 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Palate, lung, and nasal epithelium clone protein[5] (PLUNC) is a gene encoding a secretory protein. It is also called Secretory protein in upper respiratory tracts (SPURT). In humans, it is encoded by the BPIFA1 gene, previously called PLUNC.[6][7]

Function[edit]

This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the airways and nasopharyngeal regions. Plunc inhibits the epithelial sodium channel (ENaC),[8] and also has anti-microbial functions.[9] As such, plunc is believed to play a role in innate immune defense in the airways. PLUNC's ability to regulate ENaC is pH-sensitive and fails in acidic cystic fibrosis airways.[10] Thus, defective PLUNC1 function is thought to contribute to the development of lung pathology in cystic fibrosis patients.

It may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer.[11]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198183 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027483 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Ghafouri, B. "PLUNC (palate, lung and nasal epithelial clone) proteins in human nasal lavage fluid". Biochem Soc Trans. 31: 810–4. doi:10.1042/bst0310810. PMID 12887311. 
  6. ^ Bingle CD, Bingle L (Oct 2000). "Characterisation of the human plunc gene, a gene product with an upper airways and nasopharyngeal restricted expression pattern". Biochimica et Biophysica Acta. 1493 (3): 363–7. doi:10.1016/S0167-4781(00)00196-2. PMID 11018263. 
  7. ^ Iwao K, Watanabe T, Fujiwara Y, Takami K, Kodama K, Higashiyama M, Yokouchi H, Ozaki K, Monden M, Tanigami A (Feb 2001). "Isolation of a novel human lung-specific gene, LUNX, a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer". International Journal of Cancer. 91 (4): 433–7. doi:10.1002/1097-0215(200002)9999:9999<::AID-IJC1059>3.0.CO;2-B. PMID 11251963. 
  8. ^ Garcia-Caballero A, Rasmussen JE, Gaillard E, Watson MJ, Olsen JC, Donaldson SH, Stutts MJ, Tarran R (Jul 2009). "SPLUNC1 regulates airway surface liquid volume by protecting ENaC from proteolytic cleavage". Proceedings of the National Academy of Sciences of the United States of America. 106 (27): 11412–7. doi:10.1073/pnas.0903609106. PMC 2708735Freely accessible. PMID 19541605. 
  9. ^ 6
  10. ^ Garland AL, Walton WG, Coakley RD, Tan CD, Gilmore RC, Hobbs CA, Tripathy A, Clunes LA, Bencharit S, Stutts MJ, Betts L, Redinbo MR, Tarran R (Oct 2013). "Molecular basis for pH-dependent mucosal dehydration in cystic fibrosis airways". Proceedings of the National Academy of Sciences of the United States of America. 110 (40): 15973–8. doi:10.1073/pnas.1311999110. PMC 3791714Freely accessible. PMID 24043776. 
  11. ^ "Entrez Gene: PLUNC". 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.