Sorting nexin 10

SNX10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4ON3, 4PZG
Identifiers
Aliases	SNX10, OPTB8, sorting nexin 10
External IDs	OMIM: 614780; MGI: 1919232; HomoloGene: 32171; GeneCards: SNX10; OMA:SNX10 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7p15.2 Start 26,291,862 bp End 26,374,383 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 B3 Start 51,523,901 bp End 51,590,679 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus pars compacta pars reticulata pons monocyte superior vestibular nucleus Brodmann area 23 dorsolateral prefrontal cortex spinal ganglia prefrontal cortex Top expressed in granulocyte dentate gyrus of hippocampal formation granule cell facial motor nucleus hippocampus proper perirhinal cortex temporal lobe brown adipose tissue piriform cortex neural layer of retina subiculum More reference expression data BioGPS n/a
Gene ontology Molecular function ATPase binding 1-phosphatidylinositol binding protein binding phosphatidylinositol binding lipid binding Cellular component cytoplasm endosome centrosome membrane extrinsic component of endosome membrane microtubule organizing center endoplasmic reticulum endosome membrane cytoskeleton nucleus secretory granule apical cytoplasm Biological process endocytosis osteoclast differentiation endosome organization cell projection organization protein localization to cilium protein transport protein localization to centrosome cilium assembly cellular response to leukemia inhibitory factor gastric acid secretion bone mineralization tooth eruption bone resorption calcium ion homeostasis ruffle assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29887 71982 Ensembl ENSG00000086300 ENSMUSG00000038301 UniProt Q9Y5X0 Q8N5Z3 Q9CWT3 RefSeq (mRNA) NM_001199835 NM_001199837 NM_001199838 NM_013322 NM_001318198 NM_001318199 NM_001362753 NM_001362754 NM_001127348 NM_001127349 NM_028035 RefSeq (protein) NP_001186764 NP_001186766 NP_001186767 NP_001305127 NP_001305128 NP_037454 NP_001349682 NP_001349683 NP_037454.2 NP_001305128.1 NP_001120820 NP_001120821 NP_082311 NP_001348505 NP_001348506 NP_001348507 NP_001348508 NP_001348509 NP_001348510 NP_001348511 Location (UCSC) Chr 7: 26.29 – 26.37 Mb Chr 6: 51.52 – 51.59 Mb PubMed search
Wikidata
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Sorting nexin 10 is a protein that in humans is encoded by the SNX10 gene.

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. This gene may play a role in regulating endosome homeostasis. Alternative splicing results in multiple transcript variants.

Further reading

• Qin B, He M, Chen X, Pei D (2006). "Sorting nexin 10 induces giant vacuoles in mammalian cells". J. Biol. Chem. 281 (48): 36891–6. doi:10.1074/jbc.M608884200. PMID 17012226.
• Chen Y, Wu B, Xu L, Li H, Xia J, Yin W, Li Z, Shi D, Li S, Lin S, Shu X, Pei D (2012). "A SNX10/V-ATPase pathway regulates ciliogenesis in vitro and in vivo". Cell Res. 22 (2): 333–45. doi:10.1038/cr.2011.134. PMC 3271581. PMID 21844891.
• Zhu CH, Morse LR, Battaglino RA (2012). "SNX10 is required for osteoclast formation and resorption activity". J. Cell. Biochem. 113 (5): 1608–15. doi:10.1002/jcb.24029. PMID 22174188. S2CID 21535334.
• Aker M, Rouvinski A, Hashavia S, Ta-Shma A, Shaag A, Zenvirt S, Israel S, Weintraub M, Taraboulos A, Bar-Shavit Z, Elpeleg O (2012). "An SNX10 mutation causes malignant osteopetrosis of infancy". J. Med. Genet. 49 (4): 221–6. doi:10.1136/jmedgenet-2011-100520. PMID 22499339.
• Pangrazio A, Fasth A, Sbardellati A, Orchard PJ, Kasow KA, Raza J, Albayrak C, Albayrak D, Vanakker OM, De Moerloose B, Vellodi A, Notarangelo LD, Schlack C, Strauss G, Kühl JS, Caldana E, Lo Iacono N, Susani L, Kornak U, Schulz A, Vezzoni P, Villa A, Sobacchi C (2013). "SNX10 mutations define a subgroup of human autosomal recessive osteopetrosis with variable clinical severity". J. Bone Miner. Res. 28 (5): 1041–9. doi:10.1002/jbmr.1849. PMID 23280965. S2CID 23530205.
• Xu J, Xu T, Wu B, Ye Y, You X, Shu X, Pei D, Liu J (2013). "Structure of sorting nexin 11 (SNX11) reveals a novel extended phox homology (PX) domain critical for inhibition of SNX10-induced vacuolation". J. Biol. Chem. 288 (23): 16598–605. doi:10.1074/jbc.M112.449306. PMC 3675595. PMID 23615901.
• Xu T, Xu J, Ye Y, Wang Q, Shu X, Pei D, Liu J (2014). "Structure of human SNX10 reveals insights into its role in human autosomal recessive osteopetrosis". Proteins. 82 (12): 3483–9. doi:10.1002/prot.24689. PMID 25212774. S2CID 22007214.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.