Sodium tetradecyl sulfate

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Sodium tetradecyl sulfate
Sodium 7-ethyl-2-methyl-4-undecanyl sulfate.svg
Clinical data
AHFS/ Consumer Drug Information
Routes of
Intravenous injection
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Synonyms 7-Ethyl-2-methyl-4-hendecanol sulfate sodium salt
CAS Number
PubChem CID
ECHA InfoCard 100.004.892
Chemical and physical data
Formula C14H29NaO4S
Molar mass 316.43243 g/mol
3D model (Jmol)
 NYesY (what is this?)  (verify)

Sodium tetradecyl sulfate (STS) is a commonly used synonym for 7-ethyl-2-methyl-4-undecanyl sulfate sodium salt[1] which is anionic surfactant that is the active component of the sclerosant drug Sotradecol. It is commonly used in the treatment of varicose and spider veins of the leg, during the procedure of sclerotherapy. Being a detergent, its action is on the lipid molecules in the cells of the vein wall, causing inflammatory destruction of the internal lining of the vein and thrombus formation eventually leading to sclerosis of the vein. It is used in concentrations ranging from 0.1% to 3% for this purpose. In the UK, Ireland, Italy, Australia, New Zealand and South Africa, it is sold under the trade-name Fibro-Vein in concentrations of 0.2%, 0.5%, 1.0%, and 3%.[2]


It may be prepared by the aldol condensation of methyl isobutyl ketone and 2-ethylhexanal (which is itself formed by the aldol self-concensation of butyraldehyde), followed by sulfonation of the resulting alcohol.