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Sperm-associated antigen 11B

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SPAG11B
Identifiers
AliasesSPAG11B, EDDM2B, EP2, EP2C, EP2D, HE2, HE2C, SPAG11, sperm associated antigen 11B, SPAG11A
External IDsOMIM: 606560; MGI: 3647173; HomoloGene: 83383; GeneCards: SPAG11B; OMA:SPAG11B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001034905
NM_001039563
NM_001286493

RefSeq (protein)

NP_694755
NP_001030077
NP_001034652
NP_001273422

Location (UCSC)Chr 8: 7.44 – 7.46 MbChr 8: 19.19 – 19.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sperm-associated antigen 11B is a protein that in humans is encoded by the SPAG11B gene.[5][6][7]

Function

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This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined.[7]

References

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  1. ^ a b c ENSG00000274405, ENSG00000288309 GRCh38: Ensembl release 89: ENSG00000164871, ENSG00000274405, ENSG00000288309Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059463Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Osterhoff C, Kirchhoff C, Krull N, Ivell R (March 1994). "Molecular cloning and characterization of a novel human sperm antigen (HE2) specifically expressed in the proximal epididymis". Biology of Reproduction. 50 (3): 516–25. doi:10.1095/biolreprod50.3.516. PMID 8167223.
  6. ^ Kirchhoff C, Osterhoff C, Habben I, Ivell R, Kirchloff C (April 1990). "Cloning and analysis of mRNAs expressed specifically in the human epididymis". International Journal of Andrology. 13 (2): 155–67. doi:10.1111/j.1365-2605.1990.tb00972.x. PMID 1693137.
  7. ^ a b "Entrez Gene: SPAG11 sperm associated antigen 11".

Further reading

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