Squalene—-hopanol cyclase

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Squalene—-hopanol cyclase
Identifiers
EC number 4.2.1.129
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Squalene—-hopanol cyclase (EC 4.2.1.129, squalene—-hopene cyclase) is an enzyme with systematic name hopan-22-ol hydro-lyase.[1][2] This enzyme catalyses the following chemical reaction

hopan-22-ol squalene + H2O

The enzyme produces the cyclization products hopene and hopanol.

References[edit]

  1. ^ Hoshino, T.; Nakano, S.; Kondo, T.; Sato, T.; Miyoshi, A. (2004). "Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring". Org Biomol Chem. 2: 1456–1470. PMID 15136801. doi:10.1039/b401172d. 
  2. ^ Sato, T.; Kouda, M.; Hoshino, T. (2004). "Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius". Biosci. Biotechnol. Biochem. 68: 728–738. PMID 15056909. doi:10.1271/bbb.68.728. 

External links[edit]