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Synergy is the creation of a whole that is greater than the simple sum of its parts. The term synergy comes from the Attic Greek word συνεργία synergia from synergos, συνεργός, meaning "working together".
- 1 History
- 2 Descriptions and usages
- 3 Biological sciences
- 4 Human synergy
- 5 Corporate synergy
- 6 Synergistic action in economy
- 7 Computers
- 8 Synergy in literature
- 9 Synergy in the media
- 10 Obligatory synergies (medicine)
- 11 Information theory
- 12 See also
- 13 References
- 14 External links
The words "synergy" and "synergetic" have been used in the field of physiology since at least the middle of the 19th century:
SYN'ERGY, Synergi'a, Synenergi'a, (F.) Synergie; from συν, 'with,' and εργον, 'work.' A correlation or concourse of action between different organs in health; and, according to some, in disease.
- —Dunglison, Robley Medical Lexicon Blanchard and Lea, 1853
In 1896, Henri Mazel applied the term "synergy" to social psychology by writing La synergie sociale, in which he argued that Darwinian theory failed to account for "social synergy" or "social love", a collective evolutionary drive. The highest civilizations were the work not only of the elite but of the masses too; those masses must be led, however, because the crowd, a feminine and unconscious force, cannot distinguish between good and evil.
In 1909, Lester Frank Ward defined synergy as the universal constructive principle of nature:
I have characterized the social struggle as centrifugal and social solidarity as centripetal. Either alone is productive of evil consequences. Struggle is essentially destructive of the social order, while communism removes individual initiative. The one leads to disorder, the other to degeneracy. What is not seen—the truth that has no expounders—is that the wholesome, constructive movement consists in the properly ordered combination and interaction of both these principles. This is social synergy, which is a form of cosmic synergy, the universal constructive principle of nature.
- —Ward, Lester F. Glimpses of the Cosmos, volume VI (1897–1912) G. P. Putnam's Sons, 1918, p. 358
Descriptions and usages
In the natural world, synergistic phenomena are ubiquitous, ranging from physics (for example, the different combinations of quarks that produce protons and neutrons) to chemistry (a popular example is water, a compound of hydrogen and oxygen), to the cooperative interactions among the genes in genomes, the division of labor in bacterial colonies, the synergies of scale in multi-cellular organisms, as well as the many different kinds of synergies produced by socially-organized groups, from honeybee colonies to wolf packs and human societies: compare stigmergy, a mechanism of indirect coordination between agents or actions that results in the self-assembly of complex systems. Even the tools and technologies that are widespread in the natural world represent important sources of synergistic effects. The tools that enabled early hominins to become systematic big-game hunters is a primordial human example.
In the context of organizational behavior, following the view that a cohesive group is more than the sum of its parts, synergy is the ability of a group to outperform even its best individual member. These conclusions are derived from the studies conducted by Jay Hall on a number of laboratory-based group ranking and prediction tasks. He found that effective groups actively looked for the points in which they disagreed and in consequence encouraged conflicts amongst the participants in the early stages of the discussion. In contrast, the ineffective groups felt a need to establish a common view quickly, used simple decision making methods such as averaging, and focused on completing the task rather than on finding solutions they could agree on. In a technical context, its meaning is a construct or collection of different elements working together to produce results not obtainable by any of the elements alone. The elements, or parts, can include people, hardware, software, facilities, policies, documents: all things required to produce system-level results. The value added by the system as a whole, beyond that contributed independently by the parts, is created primarily by the relationship among the parts, that is, how they are interconnected. In essence, a system constitutes a set of interrelated components working together with a common objective: fulfilling some designated need.
If used in a business application, synergy means that teamwork will produce an overall better result than if each person within the group were working toward the same goal individually. However, the concept of group cohesion needs to be considered. Group cohesion is that property that is inferred from the number and strength of mutual positive attitudes among members of the group. As the group becomes more cohesive, its functioning is affected in a number of ways. First, the interactions and communication between members increase. Common goals, interests and small size all contribute to this. In addition, group member satisfaction increases as the group provides friendship and support against outside threats.
There are negative aspects of group cohesion that have an effect on group decision-making and hence on group effectiveness. There are two issues arising. The risky shift phenomenon is the tendency of a group to make decisions that are riskier than those that the group would have recommended individually. Group Polarisation is when individuals in a group begin by taking a moderate stance on an issue regarding a common value and, after having discussed it, end up taking a more extreme stance.
A second, potential negative consequence of group cohesion is group think. Group think is a mode of thinking that people engage in when they are deeply involved in cohesive group, when the members' striving for unanimity overrides their motivation to appraise realistically the alternative courses of action. Studying the events of several American policy "disasters" such as the failure to anticipate the Japanese attack on Pearl Harbor (1941) and the Bay of Pigs Invasion fiasco (1961), Irving Janis argued that they were due to the cohesive nature of the committees that made the relevant decisions.
That decisions made by committees lead to failure in a simple system is noted by Dr. Chris Elliot. His case study looked at IEEE-488, an international standard set by the leading US standards body; it led to a failure of small automation systems using the IEEE-488 standard (which codified a proprietary communications standard HP-IB). But the external devices used for communication were made by two different companies, and the incompatibility between the external devices led to a financial loss for the company. He argues that systems will be safe only if they are designed, not if they emerge by chance.
The idea of a systemic approach is endorsed by the United Kingdom Health and Safety Executive. The successful performance of the health and safety management depends upon the analyzing the causes of incidents and accidents and learning correct lessons from them. The idea is that all events (not just those causing injuries) represent failures in control, and present an opportunity for learning and improvement. UK Health and Safety Executive, Successful health and safety management (1997): this book describes the principles and management practices, which provide the basis of effective health and safety management. It sets out the issues that need to be addressed, and can be used for developing improvement programs, self-audit, or self-assessment. Its message is that organizations must manage health and safety with the same degree of expertise and to the same standards as other core business activities, if they are to effectively control risks and prevent harm to people.
- A dynamic state in which combined action is favored over the difference of individual component actions.
- Behavior of whole systems unpredicted by the behavior of their parts taken separately, known as emergent behavior.
- The cooperative action of two or more stimuli (or drugs), resulting in a different or greater response than that of the individual stimuli.
Synergy of various kinds has been advanced by Peter Corning as a causal agency that can explain the progressive evolution of complexity in living systems over the course of time. According to the Synergism Hypothesis, synergistic effects have been the drivers of cooperative relationships of all kinds and at all levels in living systems. The thesis, in a nutshell, is that synergistic effects have often provided functional advantages (economic benefits) in relation to survival and reproduction that have been favored by natural selection. The cooperating parts, elements, or individuals become, in effect, functional “units” of selection in evolutionary change. Similarly, environmental systems may react in a non-linear way to perturbations, such as climate change, so that the outcome may be greater than the sum of the individual component alterations. Synergistic responses are a complicating factor in environmental modeling.
Pest synergy would occur in a biological host organism population, where, for example, the introduction of parasite A may cause 10% fatalities, and parasite B may also cause 10% loss. When both parasites are present, the losses would normally be expected to total less than 20%, yet, in some cases, losses are significantly greater. In such cases, it is said that the parasites in combination have a synergistic effect.
Drug synergy occurs when drugs can interact in ways that enhance or magnify one or more effects, or side-effects, of those drugs. This is sometimes exploited in combination preparations, such as codeine mixed with acetaminophen or ibuprofen to enhance the action of codeine as a pain reliever. Some drug users frequently utilize 5-HTP, a serotonin precursor often used as an antidepressant, prior to and after ingestion of MDMA. It is said to increase the "high" and decreases the "comedown" stages of MDMA use, although most anecdotal evidence has pointed to 5-HTP significantly altering the effect of MDMA when used at the same time, as well as potentiating the side effects associated with serotonin syndrome). Other examples include the use of cannabis with LSD, where the active chemicals in cannabis have been reported to enhance the hallucinatory experience of LSD..
Negative effects of synergy are a form of contraindication. For example, a combination of depressant drugs that affect the central nervous system (CNS), such as alcohol and Valium, can cause a greater reaction than simply the sum of the individual effects of each drug if they were used separately. In this particular case, the most serious consequence of drug synergy is exaggerated respiratory depression, which can be fatal if left untreated. Mixing drugs can produce potentially fatal reactions within the brain, such as serotonin syndrome, due to synergistic reactions changing chemical and receptor activity. In the case of Monoamine oxidase inhibitor (MAOI) medications, mainly used as last-straw antidepressants, mixing certain foods and drugs may cause hypertension or hyperserotonemia.
Drug synergy can occur both in biological activity and because of pharmacokinetics. Shared metabolic enzymes can cause drugs to remain in the bloodstream much longer in higher concentrations than if individually taken.
A paper presenting a community computational challenge to predict synergy outlines the difficulty of predicting synergy based on high-throughput data. The Food and Drug Administration published a guideline for the pharmaceutical industry stressing the need to understand combination effects and synergy.
Drug Synergy Mechanisms
The following are further sample mechanisms that may be involved in the development of synergistic effects:
- improvement of absorption or bioavailability (bioenhancer; for example loperamide reduces the motility of the small intestine, thus increasing the absorption of many drugs absorbed in the small intestine).
- displacement of an agent from plasma proteins to which it usually binds, whereby the non-bound and thus the effective fraction of the agent is increased.
- Binding to similar receptors (e.g. two ACE inhibitors may bind to the same receptor).
- Effect on the same cellular system (e.g. two different antibiotics like a penicillin and an aminoglycoside; penicillins damage the cell wall of gram-positive bacteria and improve the penetration of aminoglycosides).
- Prevention or delay of degradation in the body (e.g. the antibiotic Ciprofloxacin inhibits the metabolism of Theophyllin).
- Slowdown of excretion (e.g. Probenecid delays the [nephron|tubular] secretion of Penicillin in the kidney and thus prolongs its effect).
- Anticounteractive action, for example the effect of oxaliplatin and irinotecan. Oxaliplatin intercalates DNA whereby the cell is not able to replicate DNA. Then, topoisomerase 1 tries to repair the damage. Irinotecan inhibits topoisomerase 1, consequently the cytostatic effect is increased
More mechanisms are described in an exhaustive 2009 review.
Toxicological synergy is of concern to the public and regulatory agencies because chemicals individually considered safe might pose unacceptable health or ecological risk in combination. Articles in scientific and lay journals include many definitions of chemical or toxicological synergy, often vague or in conflict with each other. Because toxic interactions are defined relative to the expectation under "no interaction", a determination of synergy (or antagonism) depends on what is meant by "no interaction". The United States Environmental Protection Agency has one of the more detailed and precise definitions of toxic interaction, designed to facilitate risk assessment. In their guidance documents, the no-interaction default assumption is dose addition, so synergy means a mixture response that exceeds that predicted from dose addition. The EPA emphasizes that synergy does not always make a mixture dangerous, nor does antagonism always make the mixture safe; each depends on the predicted risk under dose addition.
For example, a consequence of pesticide use is the risk of health effects. During the registration of pesticides in the United States exhaustive tests are performed to discern health effects on humans at various exposure levels. A regulatory upper limit of presence in foods is then placed on this pesticide. As long as residues in the food stay below this regulatory level, health effects are deemed highly unlikely and the food is considered safe to consume.
However, in normal agricultural practice, it is rare to use only a single pesticide. During the production of a crop, several different materials may be used. Each of them has had determined a regulatory level at which they would be considered individually safe. In many cases, a commercial pesticide is itself a combination of several chemical agents, and thus the safe levels actually represent levels of the mixture. In contrast, a combination created by the end user, such as a farmer, has rarely been tested in that combination. The potential for synergy is then unknown or estimated from data on similar combinations. This lack of information also applies to many of the chemical combinations to which humans are exposed, including residues in food, indoor air contaminants, and occupational exposures to chemicals. Some groups think that the rising rates of cancer, asthma, and other health problems may be caused by these combination exposures; others have alternative explanations. This question will likely be answered only after years of exposure by the population in general and research on chemical toxicity, usually performed on animals. Examples of pesticide synergists include Piperonyl butoxide and MGK 264.
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Human synergy relates to human interaction and teamwork. For example, say person A alone is too short to reach an apple on a tree and person B is too short as well. Once person B sits on the shoulders of person A, they are tall enough to reach the apple. In this example, the product of their synergy would be one apple. Another case would be two politicians. If each is able to gather one million votes on their own, but together they were able to appeal to 2.5 million voters, their synergy would have produced 500,000 more votes than had they each worked independently. A song is also a good example of human synergy, taking more than one musical part and putting them together to create a song that has a much more dramatic effect than each of the parts when played individually.
A third form of human synergy is when one person is able to complete two separate tasks by doing one action, for example, if a person were asked by a teacher and his boss at work to write an essay on how he could improve his work. A more visual example of this synergy is a drummer using four separate rhythms to create one drum beat.
Synergy usually arises when two persons with different complementary skills cooperate. In business, cooperation of people with organizational and technical skills happens very often. In general, the most common reason why people cooperate is that it brings a synergy. On the other hand, people tend to specialize just to be able to form groups with high synergy (see also division of labor and teamwork).
Example: Two teams in System Administration working together to combine technical and organizational skills in order to better the client experience, thus creating synergy. Counter-examples can be found in books like The Mythical Man-Month, in which the addition of additional team members is shown to have negative effects on productivity.
Organismic computing is an approach to improving group efficacy by increasing synergy in human groups via technological means.
When synergy occurs in the work place, the individuals involved get to work in a positive and supportive working environment. When individuals get to work in environments such as these, the company reaps the benefits. The authors of Creating the Best Workplace on Earth Rob Goffee and Gareth Jones, state that "highly engaged employees are, on average, 50% more likely to exceed expectations that the least-engaged workers. And companies with highly engaged people outperform firms with the most disengaged folks- by 54% in employee retention, by 89% in customer satisfaction, and by fourfold in revenue growth (Goffee & Jones, pg. 100)." Also, those that are able to be open about their views on the company, and have confidence that they will be heard, are likely to be a more organized employee who helps his/ her fellow team members succeed.
Corporate synergy occurs when corporations interact congruently. A corporate synergy refers to a financial benefit that a corporation expects to realize when it merges with or acquires another corporation. This type of synergy is a nearly ubiquitous feature of a corporate acquisition and is a negotiating point between the buyer and seller that impacts the final price both parties agree to. There are distinct types of corporate synergies, as follows.
A marketing synergy refers to the use of information campaigns, studies, and scientific discovery or experimentation for research or development. This promotes the sale of products for varied use or off-market sales as well as development of marketing tools and in several cases exaggeration of effects. It is also often a meaningless buzzword used by corporate leaders.
A revenue synergy refers to the opportunity of a combined corporate entity to generate more revenue than its two predecessor stand-alone companies would be able to generate. For example, if company A sells product X through its sales force, company B sells product Y, and company A decides to buy company B then the new company could use each sales person to sell products X and Y, thereby increasing the revenue that each sales person generates for the company.
In media revenue, synergy is the promotion and sale of a product throughout the various subsidiaries of a media conglomerate, e.g. films, soundtracks, or video games.
Financial synergy gained by the combined firm is a result of number of benefits which flow to the entity as a consequence of acquisition and merger. These benefits may be:
This is when a firm having number of cash extensive projects acquires a firm which is cash-rich, thus enabling the new combined firm to enjoy the profits from investing the cash of one firm in the projects of the other.
If two firms have no or little capacity to carry debt before individually, it is possible for them to join and gain the capacity to carry the debt through decreased gearing (leverage). This creates value for the firm, as debt is thought to be a cheaper source of finance.
It is possible for one firm to have unused tax benefits which might be offset against the profits of another after combination, thus resulting in less tax being paid. However this greatly depends on the tax law of the country.
Synergy in management and in relation to teamwork refers to the combined effort of individuals as participants of the team. The condition that exists when the organization's parts interact to produce a joint effect that is greater than the sum of the parts acting alone. Positive or negative synergies can exist. In these cases, positive synergy has positive effects such as improved efficiency in operations, greater exploitation of opportunities, and improved utilization of resources. Negative synergy on the other hand has negative effects such as: reduced efficiency of operations, decrease in quality, underutilization of resources and disequilibrium with the external environment.
A cost synergy refers to the opportunity of a combined corporate entity to reduce or eliminate expenses associated with running a business. Cost synergies are realized by eliminating positions that are viewed as duplicate within the merged entity. Examples include the headquarters office of one of the predecessor companies, certain executives, the human resources department, or other employees of the predecessor companies. This is related to the economic concept of economies of scale.
Synergistic action in economy
The synergistic action of the economic players lies within the economic phenomenon's profundity. The synergistic action gives different dimensions to competitiveness, strategy and network identity becoming an unconventional "weapon" which belongs to those who exploit the economic systems’ potential in depth.
The synergistic gravity equation (SYNGEq), according to its complex “title”, represents a synthesis of the endogenous and exogenous factors which determine the private and non-private economic decision makers to call to actions of synergistic exploitation of the economic network in which they operate. That is to say, SYNGEq constitutes a big picture of the factors/motivations which determine the entrepreneurs to contour an active synergistic network. SYNGEq includes both factors which character is changing over time (such as the competitive conditions), as well as classics factors, such as the imperative of the access to resources of the collaboration and the quick answers. The synergistic gravity equation (SINGEq) comes to be represented by the formula:
∑SYN.Act =∑R-*I(CRed+COOP++AUnimit.)*V(Cust.+Info.)*cc 
where: ∑SYN.Act = the sum of the synergistic actions adopted (by the economic actor) ∑ R- = the amount of unpurchased but necessary resources ICRed = the imperative for cost reductions ICOOP+ = the imperative for deep cooperation (functional interdependence) IAUnimit. = the imperative for purchasing unimitable competitive advantages (for the economic actor) VCust = the necessity of customer value in purchasing future profits and competitive advantages VInfo = the necessity of informational value in purchasing future profits and competitive advantages cc = the specific competitive conditions in which the economic actor operates
Synergistic networks and systems
The synergistic network represents an integrated part of the economic system which, through the coordination and control functions (of the undertaken economic actions), agrees synergies. The networks which promote synergistic actions can be divided in horizontal synergistic networks and vertical synergistic networks.
The synergy effects are difficult (even impossible) to imitate by competitors and difficult to reproduce by their authors because these effects depend on the combination of factors with time-varying characteristics. The synergy effects are often called "synergistic benefits", representing the direct and implied result of the developed/adopted synergistic actions.
Synergy can also be defined as the combination of human strengths and computer strengths, such as advanced chess. Computers can process data much more quickly than humans, but lack the ability to respond meaningfully to arbitrary stimuli.
Synergy in literature
Etymologically, the "synergy" term was first used around 1600, deriving from the Greek word “synergos”, which means “to work together” or “to cooperate”. If during this period the synergy concept was mainly used in the theological field (describing “the cooperation of human effort with divine will”), in the 19th and 20th centuries, "synergy" was promoted in physics and biochemistry, being implemented in the study of the open economic systems only in the 1960 and 1970s.
In 1938, J. R. R. Tolkien wrote an essay titled "On Fairy Stores", delivered at an Andrew Lang Lecture, and reprinted in his book, "The Tolkien Reader", published in 1966. In it, he made two references to synergy, although he did not use that term. He wrote:
Faerie cannot be caught in a net of words; for it is one of its qualities to be indescribable, though not imperceptible. It has many ingredients, but analysis will not necessarily discover the secret of the whole.
And more succinctly, in a footnote, about the "part of producing the web of an intricate story", he wrote:
It is indeed easier to unravel a single thread — an incident, a name, a motive — than to trace the history of any picture defined by many threads. For with the picture in the tapestry a new element has come in: the picture is greater than, and not explained by, the sum of the component threads.
Synergy in the media
The informational synergies which can be applied also in media involve a compression of transmission, access and use of information’s time, the flows, circuits and means of handling information being based on a complementary, integrated, transparent and coordinated use of knowledge.
In media economics, synergy is the promotion and sale of a product (and all its versions) throughout the various subsidiaries of a media conglomerate, e.g. films, soundtracks or video games. Walt Disney pioneered synergistic marketing techniques in the 1930s by granting dozens of firms the right to use his Mickey Mouse character in products and ads, and continued to market Disney media through licensing arrangements. These products can help advertise the film itself and thus help to increase the film's sales. For example, the Spider-Man films had toys of webshooters and figures of the characters made, as well as posters and games. The NBC sitcom 30 Rock often shows the power of synergy, while also poking fun at the use of the term in the corporate world. There are also different forms of synergy in popular card games like Yu-Gi-Oh!, Cardfight!! Vanguard, and Future Card Buddyfight.
In video game media a Synergist role is adapted in games, such as Square Enix's Final Fantasy XIII series to allow a character to buff up themselves or their party. In short, Synergists add resiliencies to certain attacks, lessen status ailments that are inflicted on a character, or oftentimes blocking most attacks all together.
Obligatory synergies (medicine)
When spasticity occurs, such as following a stroke, it manifests in abnormal and stereotypical patterns across multiple joints called obligatory synergies. They are described as either a flexion synergy or an extension synergy and affect both the upper and lower extremity (see below). When these patterns occur in a patient, he or she is unable to move a limb segment in isolation of the pattern. This interferes with normal activities of daily living. Some aspects of the obligatory synergy patterns however, can be cleverly used to increase function relative to the movement available to the individual. Careful thought should, therefore, be considered in deciding which muscle groups to stretch at specific times during recovery. Obligatory synergy patterns are observed when a patient tries to make a minimal voluntary movement, or as a result of stimulated reflexes.
The flexion synergy for the upper extremity includes scapular retraction and elevation, shoulder abduction and external rotation, elbow flexion, forearm supination, and wrist and finger flexion.
The extension synergy for the upper extremity includes scapular protraction, shoulder adduction and internal rotation, elbow extension, forearm pronation, and wrist and finger flexion.
The flexion synergy for the lower extremity includes hip flexion, abduction and external rotation, knee flexion, ankle dorsiflexion and inversion and toe dorsiflexion.
The extension synergy for the lower extremity includes hip extension, adduction and internal rotation, knee extension, ankle plantar flexion and inversion, and toe plantar flexion.
Note that some muscles are not usually involved in these synergy patterns and include the lattisimus dorsi, teres major, serratus anterior, finger extensors, and ankle evertors.
When multiple sources of information taken together provide more information than the sum of the information provided by each source alone, there is said to be a synergy in the sources. This in contrast to the case in which the sources provide less information, in which case there is said to be a redundancy in the sources.
- "synergy". Online Etymology Dictionary
- Werth, Margaret The Joy of Life: The Idyllic in French Art, circa 1900 University of California Press, 2002, p. 51
- Peter A. Corning, Nature's Magic: Synergy in Evolution and the Fate of Humankind, New York: Cambridge University Press 2003 ISBN 0-521-82547-4; Peter A. Corning, Holistic Darwinism: Synergy, Cybernetics and the Bioeconomics of Evolution, Chicago: University of Chicago Press 2005 ISBN 0-226-11613-1
- David Buchanan & Andrzej Huczynski: Organizational behavior, introductory text. Prentice Hall,pp 276,Third Edition 1997 ISBN 0-13-207259-9
- Benjamin Blanchard, System Engineering Management, pp 8, John Wiley 2004, ISBN 0-471-29176-5
- David Buchanan & Andrzej Huczynski: Organizational behavior, introductory text, Prentice Hall,pp 275, Third Edition 1997 ISBN 0-13-207259-9
- David Buchannan & Andrzej Huczynski: Organizational behavior, introductory text. Prentice Hall,pp 280,Third Edition 1997 ISBN 0-13-207259-9
- David Buchanan & Andrzej Huczynski: Organizational behavior, introductory text. Prentice Hall,pp 283,Third Edition 1997 ISBN 0-13-207259-9
- :Dr Chris Elliot, System safety and Law, Proceedings of First International Conference on System Safety, Institution of Engineering and Technology, London, pp 344-351(2006)
- UK Health and Safety Executive, Successful health and safety management, ISBN 978-0-7176-1276-5,(1997)
- SYNERGETICS Explorations in the Geometry of Thinking by R. Buckminster Fuller (online version)
- Fuller, R. B., (1975), “Synergetics: Explorations In The Geometry Of Thinking”, in collaboration with E.J. Applewhite. Introduction and contribution by Arthur L. Loeb. Macmillan Publishing Company, Inc., New York.
- Peter A. Corning, The Synergism Hypothesis: A Theory of Progressive Evolution, New York, McGraw Hill 1983 ISBN 0-07-013166-X; Peter A. Corning, Holistic Darwinism: Synergy, Cybernetics and the Bio economics of Evolution, Chicago,University of Chicago Press 2005 ISBN 0-226-11613-1;Synergy and self-organization in the evolution of complex systems.
- Myers, N Environmental Unknowns (1995).
- Mukesh Bansal et al.: ”A community computational challenge to predict the activity of pairs of compounds. Nature Biotechnology 32, 1213-1222, 2014
- Guidance for Industry : Codevelopment of Two or More New Investigational Drugs for Use in Combination. June 2013. http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm236669.pdf
- Kathy Moscou, Karen Snipe: Pharmacology for Pharmacy Technicians. Elsevier Health Sciences, 2012, ISBN 9780323085786, S. 56.
- Kathy Moscou, Karen Snipe: Pharmacology for Pharmacy Technicians. Elsevier Health Sciences, 2012, ISBN 9780323085786, page 57.
- K. D. Tripathi: Essentials of Medical Pharmacology G - Reference, Information and Interdisciplinary Subjects Series. JP Medical Ltd, 2013, ISBN 9789350259375, page 698.
- K. D. Tripathi: Essentials of Medical Pharmacology G - Reference, Information and Interdisciplinary Subjects Series. JP Medical Ltd, 2013, ISBN 9789350259375, page 931.
- Jia Jia et al: "Mechanisms of drug combinations: interaction and network perspectives." Nature Reviews Drug Discovery 8, 111-130, 2009
- Hertzberg, R. C., and MacDonell, M. M. (2002). Synergy and other ineffective mixture risk definitions. Sci Total Environ 288, 31-42.
- , U.S. EPA (2000). Supplementary Guidance for Conducting Health Risk Assessment of Chemical Mixtures. Risk Assessment Forum, Washington, DC.
- Pyrethroids and Pyrethrins, U.S. Environmental Protection Agency, epa.gov
- Goffee,R. & Jones, G. (2013). Creating the best workplace on the earth. Harvard Business Review, 99-106.
- Geneen, Harold; Bowers, Brent (1997). The Synergy Myth: And Other Ailments Of Business Today. St. Martin's Press. p. xii. ISBN 978-0-312-14724-2.
- Cummings, Michael S. (2001). Beyond Political Correctness: Social Transformation in the United States. Lynne Rienner Publishers. p. 92. ISBN 978-1-58826-006-2. Extract of page 92
- Lawford, G. R. (2003). Beyond success: Achieving synergy in teamwork. The Journal for Quality and Participation, 26(3), p 23.
- Cost Synergy, investopedia
- Stan Laura-Melinda, The Necessity to Exploit the Economic Network's Synergistic Potential, LAP LAMBERT Academic Publishing, Saarbrücken, Germany, 2011, p. 3-4
- Stan Laura-Melinda, The Necessity to Exploit the Economic Network's Synergistic Potential, LAP LAMBERT Academic Publishing, Saarbrücken, Germany, 2011, p. 33 and 37
- Stan Laura-Melinda, The Necessity to Exploit the Economic Network's Synergistic Potential, LAP LAMBERT Academic Publishing, Saarbrücken, Germany, 2011, p. 6-7
- Stan Laura-Melinda, The Necessity to Exploit the Economic Network's Synergistic Potential, LAP LAMBERT Academic Publishing, Saarbrücken, Germany, 2011, p. 6
- Stan Laura-Melinda, The Necessity to Exploit the Economic Network's Synergistic Potential, LAP LAMBERT Academic Publishing, Saarbrücken, Germany, 2011, p. 5
- Stan Laura-Melinda, The Necessity to Exploit the Economic Network's Synergistic Potential, LAP LAMBERT Academic Publishing, Saarbrücken, Germany, 2011, p. 9
- Campbell, Richard, Christopher R. Martin, and Bettina Fabos. Media & Culture 5: an Introduction to Mass Communication. Fifth Edition 2007 Update ed. Bostin: Bedford St. Martins, 2007. 606.
- Media Synergy see Linden Dalecki's article in Northwestern's Journal of Integrated Marketing Communications (2008) 
- 30 Rock episode 3.09; Liz: "I hate those corporate things; a bunch of drunk people talking about 'synergy'." Jack: "First of all, never badmouth 'synergy'!"
- O'Sullivan, S.B. (2007). Stroke: Motor Function. In S. B. O’Sullivan, & T. J. Schmitz (Eds.), Physical Rehabilitation (pp. 720). Philadelphia: F.A. Davis Company
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