T-cell vaccine
A T-cell vaccine is a vaccine designed to induce protective T-cells.[1]
T-cell vaccines are designed to induce cellular immunity. They are also referred to as cell-mediated immune (CMI) vaccines.[2]
It is thought that they can be more effective than conventional [B-cell] vaccines for protection from microbes that hide inside host cells, and viruses (such as HIV or influenza) that mutate rapidly.
T-cell vaccines underwent clinical trials for HIV/AIDS.[3]
As of July 2012[update] none have been approved.[4]
References
- ^ "T cell vaccines for microbial infections". Nature Medicine. 11: S25–S32. 2005. doi:10.1038/nm1212.
- ^ Buchbinder, SP; Mehrotra, DV; Duerr, A; Fitzgerald, DW; Mogg, R; Li, D; Gilbert, PB; Lama, JR; Marmor, M; Del Rio, C; McElrath, MJ; Casimiro, DR; Gottesdiener, KM; Chodakewitz, JA; Corey, L; Robertson, MN. "Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial". Lancet. 372: 1881–93. doi:10.1016/S0140-6736(08)61591-3. PMC 2721012. PMID 19012954.
- ^ "T-Cell Vaccine Strategies for Human Immunodeficiency Virus, the Virus with a Thousand Faces". 2009.
{{cite journal}}: Cite journal requires|journal=(help) - ^ "T-cell Vaccines Could Treat Elusive Diseases".
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