TAC1

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TAC1
Protein TAC1 PDB 2b19.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TAC1, Hs.2563, NK2, NKNA, NPK, TAC2, tachykinin precursor 1
External IDs MGI: 98474 HomoloGene: 2394 GeneCards: 6863
RNA expression pattern
PBB GE TAC1 206552 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_013998
NM_003182
NM_013996
NM_013997

NM_009311
NM_001311060

RefSeq (protein)

NP_003173.1
NP_054702.1
NP_054703.1
NP_054704.1

NP_033337.1

Location (UCSC) Chr 7: 97.73 – 97.74 Mb Chr 6: 7.55 – 7.57 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Preprotachykinin-1, (abbreviated PPT-1, PPT-I, or PPT-A), is a precursor protein that in humans is encoded by the TAC1 gene.[1][2]

Isoforms and derivatives[edit]

The protein has four isoforms—alpha-, beta-, gamma-, and delta-PPT—which can variably undergo post-translational modification to produce neurokinin A (formerly known as substance K) and substance P.[3][4] Alpha- and delta-PPT can only be modified to substance P, whereas beta- and gamma-PPT can produce both substance P and neurokinin A.[5]

Neurokinin A can also be further modified to produce neuropeptide K (also known as neurokinin K) and neuropeptide gamma.[6]

These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Alternative splicing of exons 4 and/or 6 produces four known products of undetermined significance.[2]

Human basal ganglia[edit]

The nature and distribution of PPT-1 has been studied in the human basal ganglia. The protein is expressed evenly throughout the caudate and putamen, and 80 to 85% of it exists in the beta-PPT isoform. 15-20% of the protein is in the gamma-PPT isoform, while no alpha-PPT was detected at all.[4]

Species comparison[edit]

In humans, beta-PPT is the dominant isoform in the brain, which contrasts with rats (predominantly gamma-PPT) and cows (alpha-PPT).[4]

While both human and rat PPT-1 produce substance P and neurokinin A, humans produce more neuropeptide K, whereas rats produce more neuropeptide gamma. In cow brains, PPT-1 primarily encodes substance P, but not other neurokinin A-derived peptides.[4]

References[edit]

  1. ^ Chiwakata C, Brackmann B, Hunt N, Davidoff M, Schulze W, Ivell R (May 1991). "Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis". Endocrinology 128 (5): 2441–8. doi:10.1210/endo-128-5-2441. PMID 1708336. 
  2. ^ a b "Entrez Gene: TAC1 tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)". 
  3. ^ Holzer, P. (1988-03-01). "Local effector functions of capsaicin-sensitive sensory nerve endings: Involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides". Neuroscience 24 (3): 739–768. doi:10.1016/0306-4522(88)90064-4. 
  4. ^ a b c d Bannon, Michael J.; Poosch, Michael S.; Haverstick, Doris M.; Anita, Mandal; Xue, Iris C. -H.; Shibata, Kazuhiko; Dragovic, Ljubisa J. (1992-01-01). "Preprotachykinin gene expression in the human basal ganglia: characterization of mRNAs and pre-mRNAs produced by alternate RNA splicing". Molecular Brain Research 12 (1–3): 225–231. doi:10.1016/0169-328X(92)90088-S. 
  5. ^ "MeSH Supplementary Concept: preprotachykinin". www.mentata.com. Retrieved 2016-05-19. 
  6. ^ Takeda, Y; Krause, JE (Jan 1989). "Neuropeptide K potently stimulates salivary gland secretion and potentiates substance P-induced salivation". Proc Natl Acad Sci U S A 86 (1): 392–396. PMC 286471. Retrieved 19 May 2016. 

Further reading[edit]