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Tachykinin, precursor 1
Protein TAC1 PDB 2b19.png
PDB rendering based on 2b19.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols TAC1 ; Hs.2563; NK2; NKNA; NPK; TAC2
External IDs OMIM162320 MGI98474 HomoloGene2394 GeneCards: TAC1 Gene
RNA expression pattern
PBB GE TAC1 206552 s at tn.png
More reference expression data
Species Human Mouse
Entrez 6863 21333
Ensembl ENSG00000006128 ENSMUSG00000061762
UniProt P20366 P41539
RefSeq (mRNA) NM_003182 NM_009311
RefSeq (protein) NP_003173 NP_033337
Location (UCSC) Chr 7:
97.73 – 97.74 Mb
Chr 6:
7.55 – 7.57 Mb
PubMed search [1] [2]

Protachykinin-1 is a protein that in humans is encoded by the TAC1 gene.[1][2]

This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Alternative splicing of exons 4 and/or 6 produces four known products of undetermined significance.[2]


  1. ^ Chiwakata C, Brackmann B, Hunt N, Davidoff M, Schulze W, Ivell R (May 1991). "Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis". Endocrinology 128 (5): 2441–8. doi:10.1210/endo-128-5-2441. PMID 1708336. 
  2. ^ a b "Entrez Gene: TAC1 tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2, neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)". 

Further reading[edit]