TAGLN

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TAGLN
Protein TAGLN PDB 1ujo.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TAGLN, SM22, SMCC, TAGLN1, WS3-10, transgelin
External IDs MGI: 106012 HomoloGene: 2398 GeneCards: 6876
RNA expression pattern
PBB GE TAGLN 205547 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003186
NM_001001522

NM_011526

RefSeq (protein)

NP_001001522.1
NP_003177.2

NP_035656.1

Location (UCSC) Chr 11: 117.2 – 117.2 Mb Chr 9: 45.93 – 45.94 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Transgelin is a protein that in humans is encoded by the TAGLN gene.[1][2][3]

The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.[3]

References[edit]

  1. ^ Kobayashi R, Kubota T, Hidaka H (Mar 1994). "Purification, characterization, and partial sequence analysis of a new 25-kDa actin-binding protein from bovine aorta: a SM22 homolog". Biochem Biophys Res Commun 198 (3): 1275–80. doi:10.1006/bbrc.1994.1180. PMID 8117285. 
  2. ^ Thweatt R, Lumpkin CK Jr, Goldstein S (Oct 1992). "A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts". Biochem Biophys Res Commun 187 (1): 1–7. doi:10.1016/S0006-291X(05)81449-4. PMID 1520290. 
  3. ^ a b "Entrez Gene: TAGLN transgelin". 

Further reading[edit]