Transgelin

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TAGLN
Protein TAGLN PDB 1ujo.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases TAGLN, SM22, SMCC, TAGLN1, WS3-10, transgelin, SM22-alpha
External IDs MGI: 106012 HomoloGene: 2398 GeneCards: TAGLN
Gene location (Human)
Chromosome 11 (human)
Chr. Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for TAGLN
Genomic location for TAGLN
Band 11q23.3 Start 117,199,321 bp[1]
End 117,204,782 bp[1]
RNA expression pattern
PBB GE TAGLN 205547 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003186
NM_001001522

NM_011526

RefSeq (protein)

NP_001001522
NP_003177

NP_035656

Location (UCSC) Chr 11: 117.2 – 117.2 Mb Chr 11: 45.93 – 45.94 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Transgelin is a protein that in humans is encoded by the TAGLN gene.[5][6][7]

The protein encoded by this gene is a transformation and shape-change sensitive actin cross-linking/gelling protein found in fibroblasts and smooth muscle. Its expression is down-regulated in many cell lines, and this down-regulation may be an early and sensitive marker for the onset of transformation. A functional role of this protein is unclear. Two transcript variants encoding the same protein have been found for this gene.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000149591 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032085 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Kobayashi R, Kubota T, Hidaka H (Mar 1994). "Purification, characterization, and partial sequence analysis of a new 25-kDa actin-binding protein from bovine aorta: a SM22 homolog". Biochem Biophys Res Commun. 198 (3): 1275–80. doi:10.1006/bbrc.1994.1180. PMID 8117285. 
  6. ^ Thweatt R, Lumpkin CK Jr, Goldstein S (Oct 1992). "A novel gene encoding a smooth muscle protein is overexpressed in senescent human fibroblasts". Biochem Biophys Res Commun. 187 (1): 1–7. doi:10.1016/S0006-291X(05)81449-4. PMID 1520290. 
  7. ^ a b "Entrez Gene: TAGLN transgelin". 

Further reading[edit]