TGIF2

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TGIF2
Identifiers
Aliases TGIF2, TGFB induced factor homeobox 2
External IDs MGI: 1915299 HomoloGene: 32514 GeneCards: TGIF2
RNA expression pattern
PBB GE TGIF2 216262 s at fs.png

PBB GE TGIF2 218724 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_021809
NM_001199513
NM_001199514
NM_001199515

NM_001291124
NM_173396

RefSeq (protein)

NP_001186442
NP_001186443
NP_001186444
NP_068581

NP_001278053.1
NP_775572.1
NP_001278053
NP_775572

Location (UCSC) Chr 20: 36.57 – 36.59 Mb Chr 2: 156.84 – 156.86 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein TGIF2 is a protein that in humans is encoded by the TGIF2 gene.[3][4]

The protein encoded by this gene is a DNA-binding homeobox protein and a transcriptional repressor. The encoded protein appears to repress transcription by recruiting histone deacetylases to TGF beta-responsive genes. This gene is amplified and overexpressed in some ovarian cancers, and mutations in this gene can cause holoprosencephaly.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Imoto I, Pimkhaokham A, Watanabe T, Saito-Ohara F, Soeda E, Inazawa J (Oct 2000). "Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines". Biochem Biophys Res Commun. 276 (1): 264–70. doi:10.1006/bbrc.2000.3449. PMID 11006116. 
  4. ^ a b "Entrez Gene: TGIF2 TGFB-induced factor homeobox 2". 

Further reading[edit]