Thrombospondin-2

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THBS2
Protein THBS2 PDB 1yo8.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTHBS2, TSP2, thrombospondin 2
External IDsOMIM: 188061 MGI: 98738 HomoloGene: 2438 GeneCards: THBS2
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for THBS2
Genomic location for THBS2
Band6q27Start169,215,780 bp[1]
End169,254,044 bp[1]
RNA expression pattern
PBB GE THBS2 203083 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003247

NM_011581

RefSeq (protein)

NP_003238

NP_035711

Location (UCSC)Chr 6: 169.22 – 169.25 MbChr 17: 14.67 – 14.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene.[5][6]

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. The role of the protein in cancer is controversial, contrasting studies show positive and negative roles for cancer development. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration.[6]

Interactions[edit]

THBS2 has been shown to interact with MMP2.[7]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186340 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023885 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, Furuichi T, Mio F, Miyake A, Miyamoto T, Ozaki K, Takahashi A, Mizuta H, Kubo T, Kimura T, Tanaka T, Toyama Y, Ikegawa S (May 2008). "A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation". American Journal of Human Genetics. 82 (5): 1122–9. doi:10.1016/j.ajhg.2008.03.013. PMC 2427305. PMID 18455130.
  6. ^ a b "Entrez Gene: THBS2 thrombospondin 2".
  7. ^ Bein K, Simons M (Oct 2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity". The Journal of Biological Chemistry. 275 (41): 32167–73. doi:10.1074/jbc.M003834200. PMID 10900205.

Further reading[edit]