Thrombospondin-2

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THBS2
Protein THBS2 PDB 1yo8.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases THBS2, TSP2, thrombospondin 2
External IDs MGI: 98738 HomoloGene: 2438 GeneCards: 7058
RNA expression pattern
PBB GE THBS2 203083 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003247

NM_011581

RefSeq (protein)

NP_003238.2

NP_035711.2

Location (UCSC) Chr 6: 169.22 – 169.25 Mb Chr 17: 14.67 – 14.69 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene.[1][2]

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein has been shown to function as a potent inhibitor of tumor growth and angiogenesis. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration.[2]

Interactions[edit]

THBS2 has been shown to interact with MMP2.[3]

References[edit]

  1. ^ Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, Furuichi T, Mio F, Miyake A, Miyamoto T, Ozaki K, Takahashi A, Mizuta H, Kubo T, Kimura T, Tanaka T, Toyama Y, Ikegawa S (May 2008). "A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation". American Journal of Human Genetics 82 (5): 1122–9. doi:10.1016/j.ajhg.2008.03.013. PMC 2427305. PMID 18455130. 
  2. ^ a b "Entrez Gene: THBS2 thrombospondin 2". 
  3. ^ Bein K, Simons M (Oct 2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity". The Journal of Biological Chemistry 275 (41): 32167–73. doi:10.1074/jbc.M003834200. PMID 10900205. 

Further reading[edit]