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Protein THBS2 PDB 1yo8.png
Available structures
PDB Ortholog search: PDBe RCSB
Aliases THBS2, TSP2, thrombospondin 2
External IDs MGI: 98738 HomoloGene: 2438 GeneCards: THBS2
Gene location (Human)
Chromosome 6 (human)
Chr. Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for THBS2
Genomic location for THBS2
Band 6q27 Start 169,215,780 bp[1]
End 169,254,044 bp[1]
RNA expression pattern
PBB GE THBS2 203083 at fs.png
More reference expression data
Species Human Mouse
RefSeq (mRNA)



RefSeq (protein)



Location (UCSC) Chr 6: 169.22 – 169.25 Mb Chr 6: 14.67 – 14.69 Mb
PubMed search [3] [4]
View/Edit Human View/Edit Mouse

Thrombospondin-2 is a protein that in humans is encoded by the THBS2 gene.[5][6]

The protein encoded by this gene belongs to the thrombospondin family. It is a disulfide-linked homotrimeric glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. The role of the protein in cancer is controversial, contrasting studies show positive and negative roles for cancer development. Studies of the mouse counterpart suggest that this protein may modulate the cell surface properties of mesenchymal cells and be involved in cell adhesion and migration.[6]


THBS2 has been shown to interact with MMP2.[7]


  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186340 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023885 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Hirose Y, Chiba K, Karasugi T, Nakajima M, Kawaguchi Y, Mikami Y, Furuichi T, Mio F, Miyake A, Miyamoto T, Ozaki K, Takahashi A, Mizuta H, Kubo T, Kimura T, Tanaka T, Toyama Y, Ikegawa S (May 2008). "A functional polymorphism in THBS2 that affects alternative splicing and MMP binding is associated with lumbar-disc herniation". American Journal of Human Genetics. 82 (5): 1122–9. doi:10.1016/j.ajhg.2008.03.013. PMC 2427305Freely accessible. PMID 18455130. 
  6. ^ a b "Entrez Gene: THBS2 thrombospondin 2". 
  7. ^ Bein K, Simons M (Oct 2000). "Thrombospondin type 1 repeats interact with matrix metalloproteinase 2. Regulation of metalloproteinase activity". The Journal of Biological Chemistry. 275 (41): 32167–73. doi:10.1074/jbc.M003834200. PMID 10900205. 

Further reading[edit]