TOM1

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TOM1
Protein TOM1 PDB 1elk.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTOM1, target of myb1 membrane trafficking protein
External IDsOMIM: 604700 MGI: 1338026 HomoloGene: 88453 GeneCards: TOM1
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for TOM1
Genomic location for TOM1
Band22q12.3Start35,299,275 bp[1]
End35,347,992 bp[1]
RNA expression pattern
PBB GE TOM1 202807 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135729
NM_001135730
NM_001135732
NM_005488

NM_001136259
NM_011622

RefSeq (protein)

NP_001129201
NP_001129202
NP_001129204
NP_005479

NP_001129731
NP_035752

Location (UCSC)Chr 22: 35.3 – 35.35 MbChr 8: 75.03 – 75.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Target of Myb protein 1 is a protein that in humans is encoded by the TOM1 gene.[5][6][7]

The specific function of this gene has not yet been determined, yet it may involve the translocation of growth factor receptor complexes to the lysosome for degradation. This gene is localized to 22q13.1, with HMOX1 and MCM5 distally and HMG2L1 proximally positioned.[7]

Interactions[edit]

TOM1 has been shown to interact with TOLLIP[8] and ZFYVE16.[9]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000100284 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042870 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seroussi E, Kedra D, Kost-Alimova M, Sandberg-Nordqvist AC, Fransson I, Jacobs JF, Fu Y, Pan HQ, Roe BA, Imreh S, Dumanski JP (Aug 1999). "TOM1 genes map to human chromosome 22q13.1 and mouse chromosome 8C1 and encode proteins similar to the endosomal proteins HGS and STAM". Genomics. 57 (3): 380–8. doi:10.1006/geno.1998.5739. PMID 10329004.
  6. ^ Katoh Y, Shiba Y, Mitsuhashi H, Yanagida Y, Takatsu H, Nakayama K (May 2004). "Tollip and Tom1 form a complex and recruit ubiquitin-conjugated proteins onto early endosomes". J Biol Chem. 279 (23): 24435–43. doi:10.1074/jbc.M400059200. PMID 15047686.
  7. ^ a b "Entrez Gene: TOM1 target of myb1 (chicken)".
  8. ^ Yamakami, Megumi; Yoshimori Tamotsu; Yokosawa Hideyoshi (Dec 2003). "Tom1, a VHS domain-containing protein, interacts with tollip, ubiquitin, and clathrin". J. Biol. Chem. 278 (52): 52865–72. doi:10.1074/jbc.M306740200. ISSN 0021-9258. PMID 14563850.
  9. ^ Seet, Li-Fong; Liu Ningsheng; Hanson Brendon J; Hong Wanjin (Feb 2004). "Endofin recruits TOM1 to endosomes". J. Biol. Chem. 279 (6): 4670–9. doi:10.1074/jbc.M311228200. ISSN 0021-9258. PMID 14613930.

Further reading[edit]

External links[edit]