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Tumor protein p53 inducible nuclear protein 1
Symbols TP53INP1 ; SIP; TP53DINP1; TP53INP1A; TP53INP1B; Teap; p53DINP1
External IDs OMIM606185 MGI1926609 HomoloGene11065 GeneCards: TP53INP1 Gene
RNA expression pattern
PBB GE TP53INP1 gnf1h01124 at tn.png
More reference expression data
Species Human Mouse
Entrez 94241 60599
Ensembl ENSG00000164938 ENSMUSG00000028211
UniProt Q96A56 Q9QXE4
RefSeq (mRNA) NM_001135733 NM_001199105
RefSeq (protein) NP_001129205 NP_001186034
Location (UCSC) Chr 8:
94.93 – 94.95 Mb
Chr 4:
11.16 – 11.17 Mb
PubMed search [1] [2]

Tumor protein p53-inducible nuclear protein 1 is a protein that in humans is encoded by the TP53INP1 gene.[1][2][3] In mice this protein is also called TRP53INP1 and is encoded by the Trp53inp1 gene. The protein is also referred to as SIP or "stress inducible protein"


TP53INP1 has been shown to interact with HIPK2[4] and p53.[1][4]


  1. ^ a b Okamura S, Arakawa H, Tanaka T, Nakanishi H, Ng CC, Taya Y, Monden M, Nakamura Y (Aug 2001). "p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis". Mol Cell 8 (1): 85–94. doi:10.1016/S1097-2765(01)00284-2. PMID 11511362. 
  2. ^ Nowak J, Tomasini R, Mattei MG, Azizi Samir LA, Dagorn JC, Dusetti N, Iovanna JL, Pebusque MJ (Nov 2002). "Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization". Cytogenet Genome Res 97 (1–2): 140E. doi:10.1159/000064049. PMID 12438758. 
  3. ^ "Entrez Gene: TP53INP1 tumor protein p53 inducible nuclear protein 1". 
  4. ^ a b Tomasini, Richard; Samir Amina Azizi; Carrier Alice; Isnardon Daniel; Cecchinelli Barbara; Soddu Silvia; Malissen Bernard; Dagorn Jean-Charles; Iovanna Juan L; Dusetti Nelson J (Sep 2003). "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity". J. Biol. Chem. (United States) 278 (39): 37722–9. doi:10.1074/jbc.M301979200. ISSN 0021-9258. PMID 12851404. 

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