TP53INP1

TP53INP1
Identifiers
Aliases	TP53INP1, SIP, TP53DINP1, TP53INP1A, TP53INP1B, Teap, p53DINP1, tumor protein p53 inducible nuclear protein 1
External IDs	OMIM: 606185; MGI: 1926609; HomoloGene: 11065; GeneCards: TP53INP1; OMA:TP53INP1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	94,949,378 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	11,174,379 bp
RNA expression pattern
	Top expressed in
	sperm; ; epithelium of nasopharynx; ; thymus; ; bronchial epithelial cell; ; mucosa of ileum; ; body of pancreas; ; visceral pleura; ; parietal pleura; ; germinal epithelium; ; palpebral conjunctiva;
	Top expressed in
	stroma of bone marrow; ; lymph node; ; thymus; ; mesenteric lymph nodes; ; Paneth cell; ; vestibular membrane of cochlear duct; ; ascending aorta; ; utricle; ; blood; ; pituitary gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	antioxidant activity; protein binding;
Cellular component	cytosol; PML body; autophagosome; cytoplasmic vesicle; nucleus; nucleoplasm; cytoplasm;
Biological process	regulation of transcription, DNA-templated; cellular response to ethanol; positive regulation of autophagy; cellular response to methyl methanesulfonate; cellular response to UV; cellular oxidant detoxification; positive regulation of apoptotic signaling pathway; response to heat; autophagosome assembly; transcription, DNA-templated; cellular response to hydroperoxide; positive regulation of transcription, DNA-templated; autophagy; negative regulation of cell migration; regulation of autophagy; positive regulation of apoptotic process; autophagic cell death; negative regulation of cell population proliferation; apoptotic process; regulation of apoptotic process; regulation of signal transduction by p53 class mediator; positive regulation of gene expression; negative regulation of gene expression; negative regulation of fibroblast proliferation; negative regulation of myofibroblast differentiation;
	Sources:Amigo / QuickGO
Orthologs
	94241
	60599
	ENSG00000164938
	ENSMUSG00000028211
	Q96A56
	Q9QXE4
	NM_001135733; NM_033285
	NM_001199105; NM_021897
	NP_001129205; NP_150601
	NP_001186034; NP_068697
	Wikidata
View/Edit Human	View/Edit Mouse

Tumor protein p53-inducible nuclear protein 1 is a protein that in humans is encoded by the TP53INP1 gene.^[5]^[6]^[7] In mice this protein is also called TRP53INP1 and is encoded by the Trp53inp1 gene. The protein is also referred to as SIP or "stress inducible protein"

Template:PBB Summary

Interactions

TP53INP1 has been shown to interact with HIPK2^[8] and p53.^[5]^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000164938 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028211 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Okamura S, Arakawa H, Tanaka T, Nakanishi H, Ng CC, Taya Y, Monden M, Nakamura Y (Aug 2001). "p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis". Mol Cell. 8 (1): 85–94. doi:10.1016/S1097-2765(01)00284-2. PMID 11511362.
^ Nowak J, Tomasini R, Mattei MG, Azizi Samir LA, Dagorn JC, Dusetti N, Iovanna JL, Pebusque MJ (Nov 2002). "Assignment of tumor protein p53 induced nuclear protein 1 (TP53INP1) gene to human chromosome band 8q22 by in situ hybridization". Cytogenet Genome Res. 97 (1–2): 140E. doi:10.1159/000064049. PMID 12438758.
^ "Entrez Gene: TP53INP1 tumor protein p53 inducible nuclear protein 1".
^ ^a ^b Tomasini, Richard; Samir Amina Azizi; Carrier Alice; Isnardon Daniel; Cecchinelli Barbara; Soddu Silvia; Malissen Bernard; Dagorn Jean-Charles; Iovanna Juan L; Dusetti Nelson J (Sep 2003). "TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity". J. Biol. Chem. 278 (39). United States: 37722–9. doi:10.1074/jbc.M301979200. ISSN 0021-9258. PMID 12851404. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)

Interactions

References

Further reading