TRIM69

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TRIM69
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesTRIM69, HSD-34, HSD34, RNF36, Trif, tripartite motif containing 69
External IDsOMIM: 616017 MGI: 1918178 HomoloGene: 18827 GeneCards: TRIM69
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for TRIM69
Genomic location for TRIM69
Band15q21.1Start44,728,988 bp[1]
End44,767,829 bp[1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_182985
NM_001301144
NM_001301145
NM_001301146
NM_080745

NM_080510

RefSeq (protein)

NP_001288073
NP_001288074
NP_001288075
NP_542783
NP_892030

NP_536771

Location (UCSC)Chr 15: 44.73 – 44.77 MbChr 2: 122.16 – 122.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tripartite motif containing 69 is a protein that in humans is encoded by the TRIM69 gene. [5]

Function[edit]

This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.

References[edit]

  1. ^ a b c ENSG00000185880 GRCh38: Ensembl release 89: ENSG00000278211, ENSG00000185880 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033368 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Tripartite motif containing 69". Retrieved 2016-02-16.

External links[edit]

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human E3 ubiquitin-protein ligase TRIM69

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.