TSC22D1

TSC22D1
Identifiers
Aliases	TSC22D1, Ptg-2, TGFB1I4, TSC22, TSC22 domain family member 1
External IDs	OMIM: 607715; MGI: 109127; HomoloGene: 7573; GeneCards: TSC22D1; OMA:TSC22D1 - orthologs
Gene location (Human)
Chr.	Chromosome 13 (human)
End	44,577,147 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	76,745,205 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; middle temporal gyrus; ; tibia; ; dorsal motor nucleus of vagus nerve; ; postcentral gyrus; ; beta cell; ; entorhinal cortex; ; mucosa of paranasal sinus; ; caput epididymis;
	Top expressed in
	iris; ; medullary collecting duct; ; renal corpuscle; ; vestibular sensory epithelium; ; epithelium of lens; ; Epithelium of choroid plexus; ; ciliary body; ; condyle; ; fossa; ; vas deferens;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus;
Biological process	regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
	8848
	21807
	ENSG00000102804
	ENSMUSG00000022010
	Q15714
	P62500
	NM_001243797; NM_001243798; NM_001243799; NM_006022; NM_183422
	NM_001177751; NM_009366; NM_207652; NM_001310646; NM_001310647
	NP_001230726; NP_001230727; NP_001230728; NP_006013; NP_904358
	NP_001171222; NP_001297575; NP_001297576; NP_033392; NP_997535
	Wikidata
View/Edit Human	View/Edit Mouse

TSC22 domain family protein 1 is a protein that in humans is encoded by the TSC22D1 gene.^[5]^[6]

TSC22 encodes a transcription factor and belongs to the large family of early response genes.^[7]

TSC22D1 forms homodimers via its conserved leucine zipper domain and heterodimerizes with TSC22D4. TSC22D1 has transcriptional repressor activity.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000102804 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022010 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Jay P, Ji JW, Marsollier C, Taviaux S, Berge-Lefranc JL, Berta P (Jul 1996). "Cloning of the human homologue of the TGF beta-stimulated clone 22 gene". Biochem Biophys Res Commun. 222 (3): 821–6. doi:10.1006/bbrc.1996.0825. PMID 8651929.
^ Ohta S, Shimekake Y, Nagata K (Mar 1997). "Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter". Eur J Biochem. 242 (3): 460–6. doi:10.1111/j.1432-1033.1996.460rr.x. PMID 9022669.
^ "Entrez Gene: TSC22D1 TSC22 domain family, member 1".
^ Kester HA, Blanchetot C, den Hertog J, van der Saag PT, van der Burg B (September 1999). "Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity". J. Biol. Chem. 274 (39): 27439–47. doi:10.1074/jbc.274.39.27439. PMID 10488076.

Shibanuma M, Kuroki T, Nose K (1992). "Isolation of a gene encoding a putative leucine zipper structure that is induced by transforming growth factor beta 1 and other growth factors". J. Biol. Chem. 267 (15): 10219–24. doi:10.1016/S0021-9258(19)50006-0. PMID 1587811.
Dmitrenko VV, Garifulin OM, Shostak EA, et al. (1997). "[The characteristics of different types of mRNA expressed in the human brain]". Tsitol. Genet. 30 (5): 41–7. PMID 9026990.
Kester HA, Blanchetot C, den Hertog J, et al. (1999). "Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity". J. Biol. Chem. 274 (39): 27439–47. doi:10.1074/jbc.274.39.27439. PMID 10488076.
Hino S, Kawamata H, Uchida D, et al. (2001). "Nuclear translocation of TSC-22 (TGF-beta-stimulated clone-22) concomitant with apoptosis: TSC-22 as a putative transcriptional regulator". Biochem. Biophys. Res. Commun. 278 (3): 659–64. doi:10.1006/bbrc.2000.3840. PMID 11095965.
Hino S, Kawamata H, Omotehara F, et al. (2002). "Leucine zipper structure of TSC-22 (TGF-beta stimulated clone-22) markedly inhibits the anchorage-independent growth of salivary gland cancer cells". Oncol. Rep. 9 (2): 371–4. doi:10.3892/or.9.2.371. PMID 11836610.
Hino S, Kawamata H, Omotehara F, et al. (2002). "Cytoplasmic TSC-22 (transforming growth factor-beta-stimulated clone-22) markedly enhances the radiation sensitivity of salivary gland cancer cells". Biochem. Biophys. Res. Commun. 292 (4): 957–63. doi:10.1006/bbrc.2002.6776. PMID 11944908.
Ohara O, Nagase T, Mitsui G, et al. (2003). "Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method". DNA Res. 9 (2): 47–57. doi:10.1093/dnares/9.2.47. PMID 12056414.
Gupta RA, Sarraf P, Brockman JA, et al. (2003). "Peroxisome proliferator-activated receptor gamma and transforming growth factor-beta pathways inhibit intestinal epithelial cell growth by regulating levels of TSC-22". J. Biol. Chem. 278 (9): 7431–8. doi:10.1074/jbc.M208076200. PMID 12468551.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Sugawara F, Yamada Y, Watanabe R, et al. (2004). "The role of the TSC-22 (-396) A/G variant in the development of diabetic nephropathy". Diabetes Res. Clin. Pract. 60 (3): 191–7. doi:10.1016/S0168-8227(03)00038-X. PMID 12757981.
Uchida D, Omotehara F, Nakashiro K, et al. (2003). "Posttranscriptional regulation of TSC-22 (TGF-beta-stimulated clone-22) gene by TGF-beta 1". Biochem. Biophys. Res. Commun. 305 (4): 846–54. doi:10.1016/S0006-291X(03)00854-4. PMID 12767908.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Choi SJ, Moon JH, Ahn YW, et al. (2005). "Tsc-22 enhances TGF-beta signaling by associating with Smad4 and induces erythroid cell differentiation". Mol. Cell. Biochem. 271 (1–2): 23–8. doi:10.1007/s11010-005-3456-7. PMID 15881652. S2CID 23414101.
Rentsch CA, Cecchini MG, Schwaninger R, et al. (2006). "Differential expression of TGFbeta-stimulated clone 22 in normal prostate and prostate cancer". Int. J. Cancer. 118 (4): 899–906. doi:10.1002/ijc.21449. PMID 16106424. S2CID 44422160.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Lu Y, Kitaura J, Oki T, et al. (2007). "Identification of TSC-22 as a potential tumor suppressor that is upregulated by Flt3-D835V but not Flt3-ITD". Leukemia. 21 (11): 2246–57. doi:10.1038/sj.leu.2404883. PMID 17690703. S2CID 2787939.

External links

TSC22D1 protein, human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 13 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000102804 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022010 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8651929-5] Jay P, Ji JW, Marsollier C, Taviaux S, Berge-Lefranc JL, Berta P (Jul 1996). "Cloning of the human homologue of the TGF beta-stimulated clone 22 gene". Biochem Biophys Res Commun. 222 (3): 821–6. doi:10.1006/bbrc.1996.0825. PMID 8651929.

[pmid9022669-6] Ohta S, Shimekake Y, Nagata K (Mar 1997). "Molecular cloning and characterization of a transcription factor for the C-type natriuretic peptide gene promoter". Eur J Biochem. 242 (3): 460–6. doi:10.1111/j.1432-1033.1996.460rr.x. PMID 9022669.

[entrez-7] "Entrez Gene: TSC22D1 TSC22 domain family, member 1".

[pmid10488076-8] Kester HA, Blanchetot C, den Hertog J, van der Saag PT, van der Burg B (September 1999). "Transforming growth factor-beta-stimulated clone-22 is a member of a family of leucine zipper proteins that can homo- and heterodimerize and has transcriptional repressor activity". J. Biol. Chem. 274 (39): 27439–47. doi:10.1074/jbc.274.39.27439. PMID 10488076.

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References

Further reading

External links