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TTI2

From Wikipedia, the free encyclopedia
TTI2
Identifiers
AliasesTTI2, C8orf41, MRT39, TELO2 interacting protein 2
External IDsOMIM: 614426; MGI: 2384576; HomoloGene: 11836; GeneCards: TTI2; OMA:TTI2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001102401
NM_001265581
NM_025115
NM_001330505

NM_001112729
NM_001199988
NM_144927

RefSeq (protein)

NP_001095871
NP_001252510
NP_001317434
NP_079391

NP_001186917
NP_659176

Location (UCSC)Chr 8: 33.47 – 33.51 MbChr 8: 31.64 – 31.65 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TELO2 interacting protein 2 is a protein that is encoded by the TTI2 gene in humans. [5]

Function

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This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1.

The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance.

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000129696Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031577Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: TELO2 interacting protein 2". Retrieved 2016-12-14.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.