TUBA1B

TUBA1B
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E4H, 4TV8, 3RYI, 3JAR, 4TUY, 4TV9, 4YJ2, 3RYH, 3JAK, 3JAS, 4F61, 3UT5, 4O4J, 4YJ3, 4EB6, 4WBN, 3JAW, 4O2A, 3RYF, 3JAL, 4O4H, 4LNU, 3J8Y, 4IIJ, 4O4I, 3RYC, 4O4L, 4O2B, 4I50, 3JAT, 4HNA, 4F6R, 3J8X, 5CA0, 5ITZ, 5JQG, 5IJ0, 5FNV, 5IJ9
Identifiers
Aliases	TUBA1B, K-ALPHA-1, tubulin alpha 1b
External IDs	OMIM: 602530; MGI: 107804; HomoloGene: 134527; GeneCards: TUBA1B; OMA:TUBA1B - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	49,131,397 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	98,832,446 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; frontal pole; ; superior frontal gyrus; ; prefrontal cortex; ; thalamus; ; Brodmann area 10; ; right frontal lobe; ; dorsolateral prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex;
	Top expressed in
	ventricular zone; ; hypothalamus; ; tail of embryo; ; mesencephalon; ; epiblast; ; neural tube; ; genital tubercle; ; dentate gyrus of hippocampal formation granule cell; ; cerebellar cortex; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; structural molecule activity; structural constituent of cytoskeleton; protein binding; GTPase activity; double-stranded RNA binding; ubiquitin protein ligase binding;
Cellular component	cytoplasm; myelin sheath; cytoplasmic microtubule; microtubule; cytoskeleton; microtubule cytoskeleton; membrane raft;
Biological process	cellular response to interleukin-4; cytoskeleton-dependent intracellular transport; cell division; microtubule-based process; microtubule cytoskeleton organization; mitotic cell cycle;
	Sources:Amigo / QuickGO
Orthologs
	10376
	22143
	ENSG00000123416
	ENSMUSG00000023004
	P68363
	P05213
	NM_006082
	NM_011654
	NP_006073
	NP_035784
	Wikidata
View/Edit Human	View/Edit Mouse

Tubulin alpha-1B chain is a protein that in humans is encoded by the TUBA1B gene.^[5]^[6]^[7] Template:PBB Summary

Interactions

TUBA1B has been shown to interact with PIK3R1.^[8] Antibodies against tubulin alpha 1b can be used as markers for microtubules and spindles.^[9]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123416 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023004 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Banerjee A (Jun 2002). "Increased levels of tyrosinated alpha-, beta(III)-, and beta(IV)-tubulin isotypes in paclitaxel-resistant MCF-7 breast cancer cells". Biochem Biophys Res Commun. 293 (1): 598–601. doi:10.1016/S0006-291X(02)00269-3. PMID 12054644.
^ Cowan NJ, Dobner PR, Fuchs EV, Cleveland DW (Jan 1984). "Expression of human alpha-tubulin genes: interspecies conservation of 3' untranslated regions". Mol Cell Biol. 3 (10): 1738–45. PMC 370035. PMID 6646120.
^ "Entrez Gene: TUBA1B tubulin, alpha 1b".
^ Kapeller, R; Toker A; Cantley L C; Carpenter C L (Oct 1995). "Phosphoinositide 3-kinase binds constitutively to alpha/beta-tubulin and binds to gamma-tubulin in response to insulin". J. Biol. Chem. 270 (43). UNITED STATES: 25985–91. doi:10.1074/jbc.270.43.25985. ISSN 0021-9258. PMID 7592789. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)CS1 maint: unflagged free DOI (link)
^ http://www.genetex.com/WebPage/Product/PromotionDetail.aspx?Type=Promotion&PromotionID=178