TXNRD1

TXNRD1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2CFY, 2J3N, 2ZZ0, 2ZZB, 2ZZC, 3QFA, 3QFB
Identifiers
Aliases	TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR, thioredoxin reductase 1
External IDs	OMIM: 601112; MGI: 1354175; HomoloGene: 55733; GeneCards: TXNRD1; OMA:TXNRD1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	104,350,307 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	82,733,546 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; islet of Langerhans; ; right adrenal gland; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; right coronary artery; ; pericardium; ; left coronary artery; ; nasal epithelium;
	Top expressed in
	somite; ; otic placode; ; otic vesicle; ; stroma of bone marrow; ; primitive streak; ; endothelial cell of lymphatic vessel; ; ganglionic eminence; ; saccule; ; epiblast; ; gastrula;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-disulfide reductase activity; methylselenol reductase activity; flavin adenine dinucleotide binding; methylseleninic acid reductase activity; protein binding; electron transfer activity; oxidoreductase activity; oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor; thioredoxin-disulfide reductase activity;
Cellular component	cytoplasm; extracellular exosome; nucleus; fibrillar center; nucleoplasm; mitochondrion; cytosol;
Biological process	nucleobase-containing small molecule interconversion; selenium compound metabolic process; signal transduction; cellular oxidant detoxification; response to oxygen radical; cell redox homeostasis; regulation of lipid metabolic process; cellular response to oxidative stress; mesoderm formation; gastrulation; cell population proliferation; electron transport chain;
	Sources:Amigo / QuickGO
Orthologs
	7296
	50493
	ENSG00000198431
	ENSMUSG00000020250
	Q16881
	Q9JMH6
NM_182743; NM_001093771; NM_001261445; NM_001261446; NM_003330;
	NM_182729; NM_182742
	NM_001042513; NM_001042514; NM_001042523; NM_015762
NP_001087240; NP_001248374; NP_001248375; NP_003321; NP_877393;
	NP_877419; NP_877420
	NP_001035978; NP_001035979; NP_001035988; NP_056577
	Wikidata
View/Edit Human	View/Edit Mouse

Thioredoxin reductase 1, cytoplasmic is an enzyme that in humans is encoded by the TXNRD1 gene.^[5]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000198431 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020250 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gasdaska PY, Gasdaska JR, Cochran S, Powis G (Nov 1995). "Cloning and sequencing of a human thioredoxin reductase". FEBS Lett. 373 (1): 5–9. doi:10.1016/0014-5793(95)01003-W. PMID 7589432.

Template:PBB Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000198431 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020250 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7589432-5] Gasdaska PY, Gasdaska JR, Cochran S, Powis G (Nov 1995). "Cloning and sequencing of a human thioredoxin reductase". FEBS Lett. 373 (1): 5–9. doi:10.1016/0014-5793(95)01003-W. PMID 7589432.

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See also

References