Talk:2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
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[edit]Thanks for your nice comments about my article. It would be nice if we could combine our articles with the heterocyclic amine article and make one comprehensive article. But I think that is beyond my skills, I think. Your table is excellent. They are a lot of work to do, so I admire the complexity of it. Carol570cjk (talk) 15:08, 23 November 2011 (UTC) Very interesting, especially the useful fact that microwaving to warm meat prior to cooking breads down creatine. I don't have much for editing but nice work!
I like what you have done. Is there anything published on carcinogenic risk from PhIP exposure that can be cited? This would frame the information in a more complete risk assessment perspective. 570jdw (talk) 16:04, 9 November 2011 (UTC)
I am currently working on incorporating studies of dose-respone in bacteria, animals, and epidemiological studies. I think it will help with the risk assessment aspect. Christi
Can you find any ranges for PhIP in either the different types of meat (pork versus chicken versus beef) or temperature correlations (140degrees in beef had ? PhIP amounts, 160 degrees had PhIP amounts) to support the data? 570nlh (talk) 15:55, 13 November 2011 (UTC)
I have included tables representing the data presented from the 3 papers cited earlier. Hope this helps! Christi
Looks well done! I think the topic seems comprehensive but could use more information about dose-response relationship. I did a quick search and didn't find any specific dosage information but if you can come up with something it would strengthen the article. Good work though! -Joe 570jby (talk) —Preceding undated comment added 19:41, 9 December 2011 (UTC).
Nice work! It may be good to point out the does-reponse relationship between PhIP intake and PhIP-DNA adduct formation. Also, I suggest pointing out uncertainties in estimating dietary pHIP intake because of food frequency questionnaires (i.e. lack of control for determining meat donness levels). Tang, D. et al. (2007). Grilled Meat Consumption and PhIP-DNA Adducts in Prostrate Carcinogenesis. Cancer Epidemiol Biomarkers Prev. 16(4):803-808. 570mpp (talk) 16:23, 16 November 2011 (UTC)