Talk:Apitoxin

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Why does the bee want one to stop bleeding?

"stop bleeding": Say if that is because the bee doesn't want you to bleed to death etc. or doesn't want you to see where he stung you or what motivation. Jidanni 16:34, 26 July 2007 (UTC)[reply]

The bee would want the venom to be anticoagulant so that it flows into its enemies body, so the venom is not bound up in a lump in the skin. I would guess. On the other side, the animal stung would want the venom coagulated to neutralise it. --SmokeyJoe (talk) 00:16, 17 February 2014 (UTC)[reply]

Why inject a cocktail of pro-algesic AND antiinflammatory agents?

Interesting point above - why a cocktail of compounds with both pro-algesic and antiinflammatory actions? Is it because the cocktail is designed for a wide range of enemies (other insects, mammals)? many thanks for your comments Thomas 168.224.1.14 (talk) 10:11, 12 February 2008 (UTC)[reply]

Acidic

I delete the mention of the toxin being acid because, while it may be true of the natural form, it need not be so in purified forms, and pH is unlikely to be highly significant to what it does. --SmokeyJoe (talk) 00:11, 17 February 2014 (UTC)[reply]

What is apic acid?

On en.wikt, we attested wikt:apic acid ("bee acid"), but we don't know exactly what it is.__Gamren (talk) 05:57, 19 September 2017 (UTC)[reply]

Properties

Why we should not specify the properties of the venom in Apitoxin? Bee venom and its components has anticancer activity.^[1]^[2]^[3]^[4]^[5] It's all Wikipedia:MEDRS (review articles published in reputable medical journals). What's wrong? Explain, please. @Zefr @Alexbrn @Jytdog --Мит Сколов (talk) 06:42, 25 September 2017 (UTC)[reply]

References

^ Son DJ, Lee JW, Lee YH, et al. Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. // Pharmacol Ther. 2007 Aug;115(2):246-70.
^ Oršolić N. (2012) Bee venom in cancer therapy. Cancer Metastasis Rev. 31: 173-194. DOI: 10.1007/s10555-011-9339-3
^ Gajski G, Garaj-Vrhovac V. Melittin: a lytic peptide with anticancer properties. // Environ Toxicol Pharmacol. 2013 Sep;36(2):697-705. doi: 10.1016/j.etap.2013.06.009.
^ Premratanachai P. and Chanchao C. (2014) Review of the anticancer activities of bee products. Asian Pac J Trop Biomed 4 (5): 337–344. doi: 10.12980/APJTB.4.2014C1262
^ Liu CC et al. Application of bee venom and its main constituent melittin for cancer treatment. // Cancer Chemother Pharmacol. 2016 Dec;78(6):1113-1130.

No reason not to, so far as I can see. But we must not imply this means in has therapeutic worth, and should be qualified by RS that there is no evidence apitherapy is of any use treating cancers (plenty of RS for that). Alexbrn (talk) 06:48, 25 September 2017 (UTC)[reply]

I think I understand you. We do not write that it is "healing", "therapeutic" or similar. It's just a substance with its properties. I later intend to add about antimicrobial and other. --Мит Сколов (talk) 06:54, 25 September 2017 (UTC)[reply]

Upd. Bee venom and its components (mostly melittin^[1]) has anticancer activity.^[2]^[3]^[4]^[5]^[6] --Мит Сколов (talk) 07:48, 25 September 2017 (UTC)[reply]

References

^ M. Diederich and K. Noworyta (eds.) (2012) Natural Compounds as Inducers of Cell Death: Volume 1 (Springer), p. 175. DOI 10.1007/978-94-007-4575-9_16
^ Son DJ, Lee JW, Lee YH, et al. Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. // Pharmacol Ther. 2007 Aug;115(2):246-70.
^ Oršolić N. (2012) Bee venom in cancer therapy. Cancer Metastasis Rev. 31: 173-194. DOI: 10.1007/s10555-011-9339-3
^ Gajski G, Garaj-Vrhovac V. Melittin: a lytic peptide with anticancer properties. // Environ Toxicol Pharmacol. 2013 Sep;36(2):697-705. doi: 10.1016/j.etap.2013.06.009.
^ Premratanachai P. and Chanchao C. (2014) Review of the anticancer activities of bee products. Asian Pac J Trop Biomed 4 (5): 337–344. doi: 10.12980/APJTB.4.2014C1262
^ Liu CC et al. Application of bee venom and its main constituent melittin for cancer treatment. // Cancer Chemother Pharmacol. 2016 Dec;78(6):1113-1130.

@Zefr You do not seem to like to communicate. But. I added all (with the exception of 1) from Index Medicus (Medline), special reviews about bee venom & cancer. (Did you see IF Pharmacol. Ther.?) But you deleted all it and added not Medline and... Read and compare... Really, I'm wrong? --Мит Сколов (talk) 17:31, 25 September 2017 (UTC)[reply]

I added a 2016 review that is more recent and comprehensive than the above references and summarizes the prevailing state of animal venom research to allow comparisons among species. There is no apparent value to using earlier sources and no established use of bee toxin as anti-cancer drugs, leaving the topic as a minority pharmaceutical development for treating cancer; see WP:MEDSCI. --Zefr (talk) 18:13, 25 September 2017 (UTC)[reply]

[1] Son DJ, Lee JW, Lee YH, et al. Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. // Pharmacol Ther. 2007 Aug;115(2):246-70.

[2] Oršolić N. (2012) Bee venom in cancer therapy. Cancer Metastasis Rev. 31: 173-194. DOI: 10.1007/s10555-011-9339-3

[3] Gajski G, Garaj-Vrhovac V. Melittin: a lytic peptide with anticancer properties. // Environ Toxicol Pharmacol. 2013 Sep;36(2):697-705. doi: 10.1016/j.etap.2013.06.009.

[4] Premratanachai P. and Chanchao C. (2014) Review of the anticancer activities of bee products. Asian Pac J Trop Biomed 4 (5): 337–344. doi: 10.12980/APJTB.4.2014C1262

[5] Liu CC et al. Application of bee venom and its main constituent melittin for cancer treatment. // Cancer Chemother Pharmacol. 2016 Dec;78(6):1113-1130.

[6] M. Diederich and K. Noworyta (eds.) (2012) Natural Compounds as Inducers of Cell Death: Volume 1 (Springer), p. 175. DOI 10.1007/978-94-007-4575-9_16

[7] Son DJ, Lee JW, Lee YH, et al. Therapeutic application of anti-arthritis, pain-releasing, and anti-cancer effects of bee venom and its constituent compounds. // Pharmacol Ther. 2007 Aug;115(2):246-70.

[8] Oršolić N. (2012) Bee venom in cancer therapy. Cancer Metastasis Rev. 31: 173-194. DOI: 10.1007/s10555-011-9339-3

[9] Gajski G, Garaj-Vrhovac V. Melittin: a lytic peptide with anticancer properties. // Environ Toxicol Pharmacol. 2013 Sep;36(2):697-705. doi: 10.1016/j.etap.2013.06.009.

[10] Premratanachai P. and Chanchao C. (2014) Review of the anticancer activities of bee products. Asian Pac J Trop Biomed 4 (5): 337–344. doi: 10.12980/APJTB.4.2014C1262

[11] Liu CC et al. Application of bee venom and its main constituent melittin for cancer treatment. // Cancer Chemother Pharmacol. 2016 Dec;78(6):1113-1130.

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