Talk:Chlorogenic acid

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Glu-6-P enzyme?[edit]

Recent studies section claims: irreversible inhibition of G-6-P enzyme. Is this refering to G6PD (dehydrogenase) or glucose-6-phosphatase? I'm assuming phosphatase, but it should be clearer. (talk) 11:49, 16 January 2008 (UTC)

sorry, wasn't logged in GetDownAdam (talk) 11:51, 16 January 2008 (UTC)

difficult to read[edit]

Am I just not getting something, or is this article written without regard to subject-verb agreement in number? For example:

Chlorogenic acid, are a family of esters of caffeic acid and quinic acid, and are a major phenolic compound in coffee, but is also found widespread ...

That passage isn't even internally consistent. It should either be "acid is" or "acids are," right?

Joe 12:14, 8 June 2007 (UTC)

Sorry should read: chlorogenic acid is a family of esters Scubafish 12:36, 8 June 2007 (UTC)

CGA in insects[edit]

somebody has any good info on how CGA acts in insects?

Did you do a Pubmed search? Scubafish 14:59, 27 July 2007 (UTC) 03:57, 29 August 2007 (UTC)"Chlorogenic acid, is a family of esters formed between certain trans cinnamic acids and (-) quinic acid", but in the picture there is cis-cinnamic acid instead of trans!

cis-trans and what cinnamic acid are we talking about anyway?[edit]

The previous poster is absolutely right; the drawing is cis. But worse still, the drawing is (correctly) a caffeate ester, while the text talks about cinnamic acids. I think it unhelpful to refer to cinnamic acids when cinnamic acid usually means HOOC-CH=CH-Ph (see also cinnamate's Wikipedia page) without the extra phenolic hydroxyl groups found on caffeate. Why not call caffeate by its own name? I'm not editing the page as I'm not an expert on CGA, and might be wrong. —Preceding unsigned comment added by (talk) 11:25, 9 October 2008 (UTC)


This article is very poorly written and full of factual difficulties. The references are abysmal. For example, the article alleged to show the chlorogenic acid can reduce the incidence of diabetes cites a correlation between increased coffee consumption and lower incidence of DM2 in men only. No specific compound was tested. Further, it was a "self-report" study, meaning it was done by questionaire. Even if chloregenic acid per se had been implicated, the study is inherently flawed. Another article was from Reuters News Service, hardly a credible source of scientific information. The antiviral/antimicrobial references again are speculative and not confined to an investigation of chlorogenic acids. Further, the methods for these rather speculative articles (9-11) are laughable. The rest of the references are equally speculative and I hope the point has been made. Personally,I would pull it. P.S. A great part of this article was taken from the following link:, which is a "Health Supplement Site." Thus I suspect this article is highly biased. — Preceding unsigned comment added by Geebe1951 (talkcontribs) 17:51, 25 February 2011 (UTC)

I removed the biomedical material. Well intentioned editors add such material and it just builds up in many articles over time. Such content is discouraged in Wikipedia unless supported by highly authoritative references.--Smokefoot (talk) 13:59, 26 February 2012 (UTC)

Speaking of biomedical material... the health effects section in particular is so jargonized that I would need a degree in biomedicine just to figure out what the heck it is saying. Could somebody please translate it into plain ol' English for us regular people? This is Wikipedia, not a physician's reference book. — Preceding unsigned comment added by (talk) 00:01, 11 May 2012 (UTC)

is this the chemical in recent "weight loss" claims for green coffee bean extract?[edit]

if so, it could be added to the article about these diet claims. — Preceding unsigned comment added by (talk) 17:35, 2 August 2013 (UTC)

Mice: Please be more specific[edit]

"The mice exposed to the nitric oxide who were pretreated with chlorogenic acid (CLA)"

Pretreated??? They fed mice with CLA extract or injected it in mice brain or something else?

To be honest, at least this page gives beter information about CLA:

And how is this study relevant compared to numerous other CLA studies one can find? — Preceding unsigned comment added by Ee1518 (talkcontribs) 14:53, 8 September 2014 (UTC)

Nonspecific future product hype/speculation, moved here to cleanup main page[edit]

It is hoped that, after subsequent larger studies in animals and humans, a special brew of coffee could ultimately be developed that would be geared toward ensuring that the retina more directly receives the CLA, as opposed to normal coffees where that may or may not be the case (alternatively, CLA-containing eye drops could also be developed) — Preceding unsigned comment added by (talk) 15:02, 5 October 2014 (UTC)

Study confirms blood pressure-lowering effect of chlorogenic acid in essential hypertension[edit]

Watanabe T1, Arai Y, Mitsui Y, Kusaura T, Okawa W, Kajihara Y, Saito I.

The blood pressure-lowering effect and safety of chlorogenic acid from green coffee bean extract in essential hypertension.

Clin Exp Hypertens. 2006 Jul;28(5):439-49.

PMID 16820341

Abstract excerpt

Chlorogenic acids (CGA) in green coffee bean extract (GCE) reduce blood pressure ... In the CGA group, but not the placebo group, blood pressure (systolic and diastolic) decreased significantly during the ingestion period. ... — Preceding unsigned comment added by (talk) 15:15, 5 October 2014 (UTC)

Raises plasma homocysteine, a coronary artery risk factor[edit]

Olthof MR1, Hollman PC, Zock PL, Katan MB

Consumption of high doses of chlorogenic acid, present in coffee, or of black tea increases plasma total homocysteine concentrations in humans.

Am J Clin Nutr. 2001 Mar;73(3):532-8. Am J Clin Nutr March 2001; vol. 73 no. 3; pgs.: 532-538

PMID 11237928

Free full text — Preceding unsigned comment added by (talk) 22:15, 5 October 2014 (UTC)

That's a pretty old paper. Think you can find a review article from within the last 5 years? TylerDurden8823 (talk) 22:35, 5 October 2014 (UTC)

Heart rate decrease (−2.56 ± 2.85 beats per minute) seen in trial of 1050 mg or 700 mg dose of green coffee bean extract[edit]

Joe A Vinson, Bryan R Burnham, and Mysore V Nagendran

Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects

Diabetes Metab Syndr Obes. 2012; 5: 21–27.

Published online Jan 18, 2012. doi: 10.2147/DMSO.S27665

PMCID: PMC3267522

This article has been cited by other articles in PMC.

... A 22-week crossover study was conducted to examine the efficacy and safety of a commercial green coffee extract product GCA™ at reducing weight and body mass in 16 overweight adults.
Subjects received high-dose GCA (1050 mg), low-dose GCA (700 mg), or placebo in separate six-week treatment periods ...
Significant reductions were observed in body weight (−8.04 ± 2.31 kg), body mass index (−2.92 ± 0.85 kg/m2), and percent body fat (−4.44% ± 2.00%), as well as a small decrease in heart rate (−2.56 ± 2.85 beats per minute), ... the decreases occurred when subjects were taking GCA. — Preceding unsigned comment added by (talk) 01:19, 6 October 2014 (UTC)
An interesting paper, but secondary sources are strongly preferred. Please see WP:MEDRS. TylerDurden8823 (talk) 05:48, 6 October 2014 (UTC)

Natural occurrences: please add a TABLE of this.[edit]

Or at least tell, how many mg per 100g of each food. Or if the food is spice, mg per dose. Nobody uses 100g dose of a spice! ee1518 (talk) 08:42, 24 April 2015 (UTC)