Talk:Cholesterol depletion

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This article is under development to look at the growing volume of research in lipidology reporting the effects of cholesterol depletion with the long term use of hmg coa reductase medications. The inhibition of de-novo cholesterol is associated with failure of cholesterol-rich lipid rafts in processes such as exocytosis and endocytosis
Glynwiki (talk) 03:29, 27 May 2009 (UTC)

Objection to deletion[edit]

deletion is being opposed as this is as serious as hypocholesterolemia but quite separate in etiology and cannot be merged without some confusion. Perhaps a rename to medically induced hypocholesterolemia is appropriate. Glynwiki (talk) 06:17, 1 June 2009 (UTC)

perhaps we could include this as a subtopic in the hypocholesterolemia thread or put a pointer there to connect this page without complicating the hypocholesterolemia focus on natural etiologies of low membrane cholesterol. Would renaming to medically induced hypocholesterolemia have been appropriate?. Glynwiki (talk) 06:43, 1 June 2009 (UTC)

Agree should be deleted[edit]

Claiming that low cholesterol causes diabetes based on a tissue culture is dishonest. Tissue cultures do NOT get diabetes.--Doc James (talk · contribs · email) 16:04, 1 June 2009 (UTC)

James this topic has been expanded to address your concerns about it. The underlying expansion of the science is very sound and the matter has now been related to a major statin trial retrospective review. Please could you be a little more helpful and express your objections in terms that can be supported by citations. I do want you to contribute. I must object to the emotive nature of the word "dishonest" and would appreciate you altering your statement accordingly - You're interest matters to me and I would like you to continue your interest.Glynwiki (talk) 11:17, 2 June 2009 (UTC)

Well let start with Hypocholesterolemia[edit]

Who classifies it? WHO, ICD10, an American organization? Looked through the titles of the refs and none of them state hypocholestolemia. Uptodate does not mention the term. It is mentioned on pubmed and a number of interesting studies but they are looking at it not as an individual seperate disease entity but as a result of severe disease. --Doc James (talk · contribs · email) 17:09, 2 June 2009 (UTC)

This Topic is part of a Lipid Raft and Cholesterol Paradigm Shift[edit]

These events are never easy for followers of orthodoxy and Doc James is right to test its veracity. That is why I chose not to use the hypocholesterolemia topic to host this. The paradigm shift within cell biology since the lipid raft hypothesis has seen a flood of research publications on Cholesterol Depletion in requiring review. My own review of this topic is already 'in press' for publication this summer and my medical co-authors have thought long and hard about this matter. It was going to be a biochemistry biophysics and cell biology matter, but my medical mentors wanted it to show full clinical implications and reference the trials data. On publication it will be cited as Wainwright G., Mascitelli L.,MD, Goldstein M. R.,MD, (2009;). "Cholesterol-Lowering Therapies and Cell Membranes". Arch Med Sci. 5.  Check date values in: |date= (help) [1]. I will post its findings here on publication. Glynwiki (talk) 11:47, 3 June 2009 (UTC)