Talk:D-dimer

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Molecular Biology: MCB

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Pregnancy info

ml as normal also apply for pregnancy? Some reference states that pregnancy can increase coagullation factors such as d-dimer and fibrin. borgx ^(talk) 01:08, 26 May 2006 (UTC)[reply]

In pregnancy, D-dimer is likely to be elevated and loses its use a diagnostic tool. No different normal range is used, because by increasing the cutoff you'd lose its sensitivity. In pregnancy clinical assessment and V/Q scanning is used. JFW | T@lk 19:06, 26 November 2006 (UTC)[reply]

ui7uhyyjg — Preceding unsigned comment added by 124.124.76.138 (talk) 06:27, 24 August 2017 (UTC)[reply]

Specificity

D-Dimer is not specific to DVT therefore all clinical details should be considered before making a diagnosis

It is not specific for anything. JFW | T@lk 19:06, 26 November 2006 (UTC)[reply]

Specificity (as in "sensitivity and specificity" of a test) has nothing to do with whether the test is specific to one disease as opposed to other diseases. Specificity means to which degree the test gives negative test result for persons for whom we know in advance that they do not have the disease in question (and do not have any of the alternative diseases either that the test might be sensitive to). Gbwi (talk) 14:12, 23 September 2013 (UTC)[reply]

UFB

The way forward: perhaps it's urinary fibrinopeptide B - see PMID 12893031. One of my seniors was waxing lyrical about its diagnostic utility. JFW | T@lk 01:18, 21 December 2006 (UTC)[reply]

Pregnancy

Normal D-dimer in pregnancy still excludes DVT[1] JFW | T@lk 06:36, 7 August 2007 (UTC)[reply]

D-dimer >3000

Finally, there is some correlation between a "whopping D-dimer" and mortality - as everyone had sneakily suspected doi:10.1111/j.1365-2141.2007.06888.x JFW | T@lk 21:24, 22 November 2007 (UTC)[reply]

Genetic variation

In European Americans, 2% of the variation in D-dimer levels is due to polymorphisms in various fibrinolysis-related genes such as fibrinogen, PAI-1 and plasminogen. In African Americans the sample was too small to establish any linkage. Fibrinogen mutations, in particular, explained D-dimer levels >20% higher than controls. doi:10.1111/j.1538-7836.2008.02906.x JFW | T@lk 10:53, 18 January 2008 (UTC)[reply]

Review

doi:10.1182/blood-2008-06-165845 could serve as a good review on the D-dimer antigen and its diagnostic relevance. JFW | T@lk 17:03, 26 March 2009 (UTC)[reply]

PMID 19684102 - meta-analysis of use of bedside test in outpatients. JFW | T@lk 23:50, 24 November 2009 (UTC)[reply]

http://atvb.ahajournals.org/cgi/content/abstract/29/3/332 may be helpful. JFW | T@lk 00:07, 25 November 2009 (UTC)[reply]

Another review with a historical angle PMID 18419743 JFW | T@lk 00:15, 25 November 2009 (UTC)[reply]

Young and health

Gor n bein (talk · contribs) added the following:

,particularly in young and healthy patients <!ref name=Qaseem>A.Qaseem; et al. (2007). "Current Diagnosis of Venous Thrombo-embolism in Primary Care:a Clinical Practice Guidelines from the American Academy of Family Physicians and the American College of Physicians". Annals of Internal Medicine. 5 (1): 57–62. {{cite journal}}: Explicit use of et al. in: |author= (help)</ref>

None of my other sources mention this age issue. I will need to read the source carefully and see if this could be mentioned. JFW | T@lk 20:52, 17 January 2010 (UTC)[reply]

What is a normal d-dimer range and units?

A normal d-dimer range is between 0 and 200 in patients with VTE this level may reach 3000 — Preceding unsigned comment added by 92.22.2.188 (talk) 17:05, 4 July 2016 (UTC)[reply]

I heard 500. Jennifer H. Jones (talk) 10:53, 23 May 2010 (UTC)[reply]

Depends on the analyser used. JFW | T@lk 07:28, 6 June 2010 (UTC)[reply]

See DVT#Notes for more explanation. Biosthmors (talk) 16:56, 11 December 2012 (UTC)[reply]

Use easy english

It should be obviously said- D dimer is used to rule out clots. It needs to be more succinct I think 182.255.99.214 (talk) 11:59, 24 November 2015 (UTC)[reply]

Detailed review

doi:10.1080/10408363.2018.1529734 JFW | T@lk 15:47, 29 April 2020 (UTC)[reply]

For ruling out clotting from Covid vaccines

In the covid vaccine resistance movement, there is much talk of microscopic blood clots. Some opponents of the vaccine, for instance from the Orange County Board of County Commissioners, suggested that every vaccinated person should get the D-dimer test to know if they have gotten clotting from the vaccine. While this is probably not the place to address the advisability of this, it should be mentioned since it is in the public discourse. — Preceding unsigned comment added by Contraverse (talk • contribs) 20:20, 22 December 2022 (UTC)Contraverse (talk) 15:42, 6 January 2023 (UTC)[reply]