Talk:Ibotenic acid

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Link issue

"Sureda, F. "Excitotoxicity and the NMDA receptor". eurosiva. Retrieved 30 April 2015."

This page and/or site has apparently been hijacked/hacked for nefarious purposes. I can't be bothered, to be honest, to learn how to deal properly with this situation so I'm flagging it up here in the hope someone else will deal with it. :) Rebtech (talk) 14:51, 25 February 2022 (UTC)[reply]

Is lesioning a medical use?

I understand Medicine to be a science that cures illnesses; how can it be that causing lesions to the brain is listed as a medical use? What can you cure by destroying brain-cells? Thanks for answering this question.

MiG-25 12:27, 18 April 2007 (UTC)[reply]

Ibotenic acid is an unstable compound and decarboxylates into muscimol. The Ibotenic acid is most concentrated under the amanita muscaria's red skin. — Preceding unsigned comment added by 86.27.69.241 (talk) 22:07, 2007 June 20 (UTC)

zolpidem comparison

I can understand why it is tempting to compare the effects of ibotenic acid and muscimol to zolpidem and other z-drugs, since both act on the GABA-system. nevertheless, it doesn't work out, since there are significant pharmacological differences: zolpidem (and other z-drugs) act as GABA receptor modulators, just in the same way as benzodiazepines do. muscimol, on the other hand, is a direct agonist on the GABA receptor. and if this subtile scientific difference doesn't convince you: I have extensive experience with the psychoactive use of both zolpidem and amanita muscaria mushrooms, and I can assure you that they are not alike at all. zolpidem produces an alcohole-like intoxication with pronounced memory loss, which is only occasionally accompanied by slight hallucinations. amanita muscaria, on the other hand, is an extremely potent entheogen, which produces profound changes in the perception of time, space and self. IMHO it is one of the most profound psychedelics there is, which compares in no way with the dull intoxication zoplidem provides. --Diogenes2000 (talk) 00:20, 24 August 2012 (UTC)[reply]

Revisions as part of chemistry project

The recent revisions to the article were part of an assignment for a chemistry course (The Chemistry of Poisons, I am the instructor). The student is working on further improving the quality of the article based on the notes in the revision history, which were helpful and appreciated. I am posting to put the revisions in context, and clarify the focus on chemistry. Hopefully consensus can be reached on what topics are appropriate to include in the article. Ajfrontier (talk) 23:24, 4 May 2015 (UTC)[reply]

Contradiction on the use of atropine as treatment

Hi, I encourage anyone competent enough in toxicology/biochemistry and the likes to read both sources cited in the contradiction. More precisely the Michelot reference, which i cite since in the paragraph on treatment (end of second page to third) they mention never using atropine, and the Rolston-Cregler reference which first of all I can not even access myself. The statement on atropine on this page is misinformation from what I can gather. Again I have not enough knowledge on the subject to delete it myself, but I hope someone who has the aforementioned knowledge will stumble upon this page and correct it.

No matter what the truth is on this subject there's a contradiction in what is said in a reference and the wiki article which is problematic on it's own. — Preceding unsigned comment added by Toucanite (talk • contribs) 13:36, 11 December 2021 (UTC)[reply]

The Rolston-Cregler reference sates:

With A muscaria poisoning, despite the implications of the species name, few muscarinic effects are observed; consequently, anticholinergic drugs such as atropine are rarely, if ever, needed.

. So what is currently stated in the article is technically true, but misleading and irrelevant anyway because any muscarinic effects would be related to the (low concentration) muscarine content of A muscaria and related mushrooms rather than the ibotenic acid/muscimol. Michelot notes atropine-like (anticholinergic) toxicity can occur, but again this may be better suited in the articles on the mushrooms themselves rather than on the page for the chemical. I have edited to remove reference to both IeuanDwI (talk) 11:55, 1 November 2023 (UTC)[reply]