Talk:Kinetic exclusion assay

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Tomofidabio (talk · contribs) has been paid by Sapidyne Instruments Inc.
Tomsapid (talk · contribs) has been paid by Sapidyne Instruments Inc.

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Request edit on 24 July 2022

This edit request by an editor with a conflict of interest was declined. [see below]

What I think should be changed:
Why it should be changed:
References supporting the possible change (format using the "cite" button):

Hi, Myself, Thomas Glass and my partner Steve Lackie are the named inventors on the KinExA method for bioassay. We founded Sapidyne Instruments which makes and sells the only Kinetic exclusion instruments on the market. I created the page but acknowledged that I was paid and did my very best comply with Wikipedia's rules and customs. I can't see in the revisions when it was removed but the following short final paragraph was (I beleive) included in the original posting and I would like it put back.

History Kinetic exclusion assay was pioneered in 1995 by the founders of Sapidyne Instruments Inc., a scientific instrument manufacturer located in Boise, Idaho, USA.

This is a correct and true summary of the history of Kinetic Exclusion and should be included for completeness on the Wikipedia page. It als provides a direction for any readers hoping to learn more.

I do NOT wish to add the patent info to the page but I include this info below so you can see one of our patents covering kinetic exclusion

Solid phase assay for detection of ligands Patent number: 7091050 Abstract: The present invention provides an improved system for detecting the presence or level of an analyte in a sample. In “competition-like” assays of the present invention, a sample including an analyte is mixed with a second ligand to which the analyte binds, and the mixture is exposed to a solid phase containing a first ligand that can compete with the analyte for binding to the second ligand. According to the present invention, the time of exposure of the mixture to the solid phase is limited so that substantially no dissociation of analyte/second ligand complex occurs. The competition-like assays of the present invention are preferably performed with a solid phase containing a substantial excess of first ligand. In “sandwich-type” assays of the present invention, a sample including an analyte is contacted with a solid phase including a first ligand that binds the analyte and, simultaneously or subsequently, is contacted with a second ligand that binds the analyte (or the analyte/first ligand complex). Type: Grant Filed: October 22, 2003 Date of Patent: August 15, 2006 Assignee: Sapidyne Instruments Inc. Inventors: Steve J. Lackie, Thomas R. Glass

Tomsapid (talk) 18:11, 27 July 2022 (UTC)[reply]

References

Not done no independent source provided. Theroadislong (talk) 19:45, 27 July 2022 (UTC)[reply]

Thank you for considering my request. Can you please give an example of the kind of independent source you're looking for? I had hoped the patent abstract from one of our patents on kinetic exclusion would fill this need but if not, what would? Tomofidabio (talk) 13:20, 1 August 2022 (UTC)[reply]

It would need to have been reported by a reliable independent source, newspaper, magazine article, scientific journal etc. The patent abstract is a primary source. Theroadislong (talk) 13:33, 1 August 2022 (UTC)[reply]

would this reference be acceptable?

Robert C. Blake II, Andrey R. Pavlov, and Diane A. Blake. Analytical Biochemistry 272, 123–134 (1999) Article ID abio.1999.4176, available online at http://www.idealibrary.com Automated Kinetic Exclusion Assays to Quantify Protein Binding Interactions in Homogeneous Solution

this is the first independent peer reviewed publication on kinetic exclusion assay and includes the sentence "Equilibrium and kinetic measurements of antibody–antigen binding interactions were performed with a beta unit of the KinExA 3000 immunoassay instrument (Sapidyne Instruments, Inc.)." Tomofidabio (talk) 20:32, 2 August 2022 (UTC)[reply]

please add short history section

Specific text to be added or removed: History: Kinetic exclusion assay was pioneered in 1995 by the founders of Sapidyne Instruments Inc., a scientific instrument manufacturer located in Boise, Idaho, USA.

Reason for the change: This is a correct and true summary of the history of Kinetic Exclusion and should be included for completeness on the Wikipedia page. It also provides a direction for any readers hoping to learn more.

References supporting change: Robert C. Blake II, Andrey R. Pavlov, and Diane A. Blake. Analytical Biochemistry 272, 123–134 (1999) Article ID abio.1999.4176 Tomofidabio (talk) 18:40, 9 August 2022 (UTC)[reply]