Jump to content

Talk:List of medicine contamination incidents

Page contents not supported in other languages.
From Wikipedia, the free encyclopedia
[edit]

Hello fellow Wikipedians,

I have just modified one external link on List of medicine contamination incidents. Please take a moment to review my edit. If you have any questions, or need the bot to ignore the links, or the page altogether, please visit this simple FaQ for additional information. I made the following changes:

When you have finished reviewing my changes, you may follow the instructions on the template below to fix any issues with the URLs.

This message was posted before February 2018. After February 2018, "External links modified" talk page sections are no longer generated or monitored by InternetArchiveBot. No special action is required regarding these talk page notices, other than regular verification using the archive tool instructions below. Editors have permission to delete these "External links modified" talk page sections if they want to de-clutter talk pages, but see the RfC before doing mass systematic removals. This message is updated dynamically through the template {{source check}} (last update: 5 June 2024).

  • If you have discovered URLs which were erroneously considered dead by the bot, you can report them with this tool.
  • If you found an error with any archives or the URLs themselves, you can fix them with this tool.

Cheers.—InternetArchiveBot (Report bug) 10:21, 31 December 2017 (UTC)[reply]

2012-2019 Contamination of Angiotensin II Inhibitor ("Sartan") Medications with N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA)

[edit]

Beginning in 2012, the process for making tetrazole, a chemical intermediate in the production of various angiotensin II inhibitor medications for hypertension (popularly known by their common drug name suffix "sartan") was changed by generic drug manufacturers in favor of several cheaper and more efficient processes. These processes caused tetrazole to be contaminated with N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) which cause genetic damage and cancer according to a report by German researcher Professor Dr. Fritz Sörgel.

This contamination was not detected until 2018. In the intervening years massive amounts of generic versions of angiotensin II inhibitor ("Sartan") blood pressure medications were made with contaminated tetrazole. Patients receiving these drugs were exposed to genotoxic and carcinogenic N-nitrosodimethylamine (NDMA) and N-nitrosodiethylamine (NDEA) from 2012 until the drugs were recalled from the world drug market in 2018. The incident, according to a column by medicinal chemist and pharmaceutical industry blogger Dr. Derek Lowe, points to a greater problem. Generic drug manufacturers often change the way in which prescriptiion drug ingredients are made in order to save costs of making them. So this kind of contamination incident may not be isolated.

I'm throwing this out there hoping for some discussion before I change our article to include this rather large, extensive, alarming and notable contamination incident. --loupgarous (talk) 00:56, 17 April 2020 (UTC)[reply]