|WikiProject Molecular and Cell Biology||(Rated Start-class, Mid-importance)|
|WikiProject Neuroscience||(Rated Start-class, High-importance)|
From the article: "Despite its name, BDNF is actually found in a range of tissue and cell types, not just the brain. Expression can be seen in the retina, the CNS, motor neurons, the kidneys, the prostate and post-katiemorgan circuit"
Is there really such a thing as a post-katiemorgan circuit? I couldn't find any sign of it in a Google search but I did find links to people named Katie Morgan, one of whom appears to be a "porn star"...
There are much more neurotrophins then mentioned in this article. The ones mentioned here are from the NGF-family only, but there are others like glial cell derived neurotrophic factor (GDNF) and ciliary neurotrophic factor (CNTF). Unfortunately, I don't know enough about those. Methoxyroxy 16:06, 16 June 2006 (UTC)
I can add in a discussion on GDNF, CNTF, etc...
The question is how broad one should go. For example, IGF-1 is neuro-protective, but most people would not classify it as a "neurotrophin" despite the fact that it has "neurotrophic factor activity."
Gacggt 22:56, 17 June 2006 (UTC)
I added references for three review articles, which both confirm the information given so far, and which give extensive further sourcing. Therefore I removed the tag.Gacggt 18:49, 27 June 2006 (UTC)
- Excellent... thanks.--Isotope23 12:27, 28 June 2006 (UTC)
neurones or tissue, "target neurones"?
THe beginning needs more specifity and possibly more precision. The sense I get is that the cells a neurone connects to protect it from destroying itself by producing trophic factors. "Target neurones" doesn't seem to be quite th eright phrase, at least on that basis. Midgley 17:09, 8 July 2006 (UTC)
I find it strange that the "main article" for Neurotrophin-4 is NT-4, whereas the main articles for brain-derived neurotrophic factor, neurotrophin-3, nerve growth factor, etc. all point to "main" articles titled with their full name. If no one objects, I would suggest pointing to "Neurotrophin-4" instead of NT-4 (and, of course, moving all relevant information to that article). Jamestttgrays (talk) 03:51, 14 May 2008 (UTC)
I've moved some of this text to the NT-3 page. Some of it could go to the p75 page too. It's too specific for this overview.
This is different to other studies which shows a dimer of nerve growth factor (NGF) bound to a single ectodomain of deglycosylated p75(NTR), resulting in an asymmetrical crystal structure. The crystal structure of NT-3 shows that NT-3 forms a central homodimer around which two glycosylated p75 (NRT) molecules bind symmetrically. The symmetrical binding takes place along the NT-3 interfaces, resulting in a 2:2 ligand-receptor cluster in the center. The symmetrical and asymmetrical structures show that there is a significant difference in ligand-receptor interactions and p75 (NRT) conformations. This symmetrical complex indicates that p75(NRT) activates at the cell surface. In addition, this symmetrical crystal structure provides a model for NTs-p75(NTR) recognition and signal generation, as well as insights into coordination between p75(NTR) and Trks.