Talk:Simulated moving bed

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The post is highly misleading and provides information which is incorrect. Please remove —Preceding unsigned comment added by (talkcontribs)

Please explain how it is misleading and what is incorrect, with sources. Rich Farmbrough, 15:14 9 December 2006 (GMT).

Simulation and stimulation[edit]

Richard, It was a great surprise to me to read about a simulated chromatography in the C. article.

My suspicion was, that the name ought to be stimulation, not simulation, because one could easily imagine a method whereby the separation is stimulated by some method, but why should one simulte chromatography? Why not use the real thing? (simulation= imitation, pretending, feigning)

When I searched Google for both terms it appeared that indeed there were several citations for stimulated chromatography, and stimulation effects, using stimulation in connection with chromatography, but, to my greatest surprise, there were also numerous citations on simulated chromatography.

In spite of all this my suspicion is, that the original citation that used the simulation term was the culprit, who used it erroneously, and the expression, like many others, have become propagated by the bandwagon effect.

Infact what the intro says is that through the arrangement the separation is enhanced, meaning, that it is stimulated, which supports my suspicion.

However, if you can explain what is simulated I shall be pleased to change my view.

As a further comment: I have noted that somebody stuck an orphaned and remove label on the article. There are plenty of citations in Google, as I said, and I would support keeping the article, but it would be necessary to clarify which name is correct (for which we might have to go back in history some way) and then its name ought also be explained in its intro paragraph. LouisBB (talk) 20:31, 6 May 2008 (UTC)

I have made a long search on Google and it has transpired what the meaning of simulation is,, which appears to be absolutely correct. The earliest find is the description in the book which I have inserted into the article. Indeed the literature on this is pretty large. I now understand that in the technique side-entry of the sample into the column continuously changes giving the impression that the bed moves. This way the static bed becomes continuous and the speed of separation increases.

LouisBB (talk) 21:34, 6 May 2008 (UTC)

RE:Stimulation vs. Simulation:[edit]

The way I understand it is that it is the "moving" that is being simulated by the valve switching. Quafthis (talk) 00:10, 30 January 2009 (UTC)

I have never contributed to or edited for Wikipedia before, so I am not sure if I am doing this correctly. This article is not really very misleading, it just isn't very clear and does not give the background which would help technically savvy chemists or engineers to understand the process, unless they happened to have worked in a field which uses SMB (Simulated Moving Bed) chromatography. I worked for over 20 years and focused primarily on the SMB technology.

After I retired from my corporate job, I formed my own consulting firm. I still work with SMB technology. It is a significant technology and there are billions of pounds of products manufactured each year which cannot be produced at a reasonable price with any other technology. All non-diet soft drinks (Coke, Pepsi, Seven-up, . . . ) use ingredients made available by Simulated Moving Bed Chromatographic separation.

Yes, the correct term is "simulated." SMB is a counter-current purification process that uses a solid and a liquid with different 'affinities' for two or more compounds dissolved in a moving solvent. TMB, True Moving Bed chromatography would use a fixed container with two openings at opposite ends of the container but with the solid moving in one direction and the liquid moving in the other direction. This has been attempted, but without practical success.

SMB, Simulated Moving Bed chromatography simulates the movement of the solid and liquid phases in opposite directions by connecting multiple 'containers' in a loop and moving the liquid inlets and outlets. There is much more to explain before it would make sense.

I would be able to supply more detail on this technology ---- but I probably cannot do much in the next year. I will see if I can provide something short and sweet that will at least make this article better than it currently is. But this is important technology and I suggest that the article NOT be deleted. NOTE: this is really more of an ENGINEERING subject than it is a CHEMISTRY subject; SMB is a very elegant, advanced, highly-developed purification process that implements chromatographic separation for the purpose of industrial purification and the production of various products, including sugars, proteins, petrochemicals, and drugs. PRIMESEP (talk) 01:41, 11 December 2014 (UTC)Bruce P