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The story of the discovery of streptomycin, and in particular the question of who should have received the credit, seems quite controversial. This would probably require some editing to explain the situation better; in the meantime, the Revision as of 09:36, 3 September 2005 by User:The Phoenix seems more neutral than the subsequent revision by User:Gwax. I suggest to revert this edit until a better formulation is found. Schutz 21:37, 29 September 2005 (UTC)
Streptomycin - used in treatment for Pneumonic plague
Secondary pneumonic plague can be simplistically considered as an evolved form of bubonic plague where bacterial infection spreads to the lungs resulting in symptoms consistent with those of TB. It should be noted that the symptoms of secondary pneumonic plague are of rapid onset (2-3 days) and much higher severity than those seen in tuberculosis infection. Untreated pneumonic plague is almost uniformly fatal.
Stremptomycin has been shown to be somewhat effective in treatment - usually following use of other antibiotics such as tetracycline where treatment has been unsuccessful - possibly due to treatment being applied too late in the disease cycle.
More advanced treatments may now exist - do not use the above as medical advice - seek professional medical advice.
What does this mean ?
"However It is approved for this purpose only by the U.S. Food and Drug Administration."
Does this mean that the US FDA approves the drug for treating plague but not for any other use, or does it mean that no other authority than the US FDA approves the drug for use against plague ? g4oep — Preceding unsigned comment added by 188.8.131.52 (talk) 16:12, 30 October 2014 (UTC)
As has already been seen, I am not neutral on the matter of this article so I won't try editing it myself but in its current state it exibits a strong bias (almost slander) against Selman Waksman and as such I have placed the NPOV tag on the page. Both the Albert Schatz and Selman Waksman pages present a more neutral appraoch to the issue. --Gwax 21:04, 22 December 2005 (UTC)
After researching this interesting story on the discovery of streptomycin for a class that I teach, I agree that the current listing on Wikipedia for streptomycin exhibits a strong bias against Selman Waksman (and as stated above, bordering on slander). The story of Selman Waksman on the Wikipedia site shows a much more balanced view of the controvery. UMIMPMI 14:51, 7 February 2006 (UTC)
I have now edited this page to present a neutral and more comprehensive discussion of this topic UMIMPMI 15:30, 7 February 2006 (UTC)
- It looks good to me; I think the tag can be removed. Schutz 15:34, 7 February 2006 (UTC)
wrong chemical structure
the submitted image of the chemical structure is incorrect,the IUPAC name for streptomycin is : 5-(2,4-diguanidino-3,5,6-trihydroxy-cyclohexoxy)-4- [4,5-dihydroxy-6-(hydroxymethyl) -3-methylamino-tetrahydropyran-2-yl] oxy-3-hydroxy-2-methyl-tetrahydrofuran-3-carbaldehyde
the bold states a methyl group at the 2-position in the furan ( 5 membered one in the middle) and the image contains a hydroxyl group
The unsigned contributor above is correct. For example, see the chemical structure at http://www.bmb.leeds.ac.uk/mbiology/ug/ugteach/icu8/antibiotics/antimycobacterials.html susato 16:06, 19 October 2007 (UTC)
The depicted chemical structure has incorrect stereochemistry and is, I believe, instead the enantiomer of streptomycin, as can be seen from https://pubchem.ncbi.nlm.nih.gov/compound/streptomycin#section=2D-Structure Harmonslide (talk) 04:35, 28 May 2015 (UTC)
Simple English Possible?
Would it be possible to make a simple english version of this... please? 184.108.40.206 16:49, 18 March 2007 (UTC)
First line for TB
Although streptomycin is not commonly used as first-line treatment for TB, this is not because it is not a first line drug! Indeed, it IS on the WHO list of first line drugs for TB. It is because streptomycin has to be given by daily intramuscular injection, which is painful and one of the major side-effects of streptomycin is permanent sensorineural deafness. If there are no objections, I will amend the article to reflect this. --Gak 02:55, 18 May 2007 (UTC)
This article claims that E. coli can be resistant to streptomycin if they have an aadA gene activated, and then cites a Joung 2000 article, found at http://www.pnas.org/cgi/content/full/97/13/7382 This article makes absolutely no mention of streptomycin, but rather of resistance to spectinomycin. Spectinomycin is produced by a bacterium from the same genus as streptomycin, but not the same species. Even though spectinomycin behaves similarly to streptomycin, they have different chemical structures and I think it's an unethical extrapolation to assume that activation of the aadA gene will also create resistance to streptomycin. —Preceding unsigned comment added by 220.127.116.11 (talk) 04:55, 9 May 2008 (UTC)
- I agree. I checked the citations today, and you are correct. All references that were provided in the respective section ("Bacteria selection experiments") were "Joung et al., 2000" and "Hurt et al., 2003", which is not very helpful. Fortunately, Joung is a rather rare name (as opposed to Young and Jung, of which there are thousands). PubMed lists only four articles with a Joung as first author that were published in 2000 (), and the only one of them that deals with the aadA gene is the one you cited, so it is probably the one being referred to. Streptomycin is not even mentioned in the article, so I suppose the guy who wrote the section confused it with Spectinomycin, which is one of the antibiotics the paper deals with. I removed the section for this reason.
- If you or anyone else discovers a similar mistake in the future, just be bold and fix it. -- Shinryuu (talk) 17:03, 25 May 2010 (UTC)
History and discussion of placebo controlled and double blind
The comments about whether or not the study was placebo controlled, double blind or fair should probably be deleted. They don't add to the article. By what criteria is it not "fair"? Franklinjefferson (talk) 04:51, 9 February 2009 (UTC)
"Streptomycin cannot be given orally, but must be administered by regular intramuscular injections." - Okay. So how do I have it in tablet form? Those tablets useless? Quizzically... -- 18.104.22.168 (talk) 04:29, 10 January 2012 (UTC) I think its erythromycin or neomycin