Tectonin beta-propeller repeat containing 1

TECPR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4TQ1
Identifiers
Aliases	TECPR1, tectonin beta-propeller repeat containing 1
External IDs	OMIM: 614781; MGI: 1917631; HomoloGene: 9120; GeneCards: TECPR1; OMA:TECPR1 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	98,252,232 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	144,160,433 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; pancreatic ductal cell; ; mucosa of ileum; ; endothelial cell; ; sural nerve; ; trachea; ; granulocyte; ; middle temporal gyrus; ; prefrontal cortex; ; tibialis anterior muscle;
	Top expressed in
	lacrimal gland; ; Rostral migratory stream; ; cerebellar cortex; ; internal carotid artery; ; iris; ; motor neuron; ; thymus; ; substantia nigra; ; neural layer of retina; ; external carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; phosphatidylinositol-3-phosphate binding; lipid binding;
Cellular component	integral component of membrane; lysosomal membrane; autophagosome membrane; lysosome; cytoplasmic vesicle; membrane; nucleoplasm; intracellular membrane-bounded organelle;
Biological process	autophagy; autophagosome maturation;
	Sources:Amigo / QuickGO
Orthologs
	25851
	70381
	ENSG00000205356
	ENSMUSG00000066621
	Q7Z6L1
	Q80VP0
	NM_015395
	NM_027410; NM_001356992; NM_001356993
	NP_056210
	NP_081686; NP_001343921; NP_001343922
	Wikidata
View/Edit Human	View/Edit Mouse

Tectonin beta-propeller repeat containing 1 is a protein that in humans is encoded by the TECPR1 gene. ^[5]

Function

This gene encodes a tethering factor involved in autophagy. The encoded protein is found at autolysosomes, and is involved in targeting protein aggregates, damaged mitochondria, and bacterial pathogens for autophagy

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000205356 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000066621 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Tectonin beta-propeller repeat containing 1". Retrieved 2017-01-03.

Function

References

Further reading